False negative high density lipoprotein-cholesterol in an autoimmune hepatitis patient: Case report [Otoimmün hepatitli bir olguda yanlis-negatif yüksek yogunluklu lipoprotein-kolesterol]
Küçük Resim Yok
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkiye Klinikleri
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
False-negative high density lipoprotein-cholesterol (HDL-C) detection is a remarkable condition in clinical laboratory practice. We report an 18-year-old female who admitted to transplantation division, with cirrhotic process of autoimmune hepatitis in which polyclonal hypergammaglobulinemia negatively interfered with HDL-C. The HDL-C and immunoglobulin G (IgG) levels were measured before and after liver transplantation. The patient had high IgG with polyclonal hypergammaglobulinemia and an undetectable HDL-C before transplantation. Falsely undetectable HDL-C levels were ruled out by two easy methods: sample dilution and back calculation based on Friedewald formula. This false negative value of HDL-C was also confirmed with lipoprotein electrophoresis. One must be careful in hyperimmunglobulinemic patients when using direct homogeneous HDL-C assay. © 2010 by Türkiye Klinikleri.
Açıklama
Anahtar Kelimeler
Autoimmune, Cholesterol, HDL, Hepatitis, Hypergammaglobulinemia
Kaynak
Turkiye Klinikleri Journal of Medical Sciences
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
30
Sayı
1
