The effect of inhaled nitric oxide therapy on thromboelastogram in newborns with persistent pulmonary hypertension

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dc.contributor.authorTanriverdi, Sema
dc.contributor.authorKoroglu, Ozge Altun
dc.contributor.authorUygur, Ozgun
dc.contributor.authorBalkan, Can
dc.contributor.authorYalaz, Mehmet
dc.contributor.authorKultursay, Nilgun
dc.date.accessioned2019-10-27T22:12:56Z
dc.date.available2019-10-27T22:12:56Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractStudies about the effects of inhaled nitric oxide (iNO) on bleeding time and platelet aggregation in newborns are limited in number and have inconclusive results. Thromboelastogram (TEG) shows the combined effects of coagulation factors and platelet functions. In this preliminary study, we aimed to evaluate the effects of iNO on coagulation using TEG in newborns with persistent pulmonary hypertension (PPH). TEG assays were performed in 10 term infants receiving iNO treatment for PPH and 32 healthy term infants. Samples of the iNO group were collected before and during iNO. Clot reaction time (R), clot kinetics (K), maximum amplitude (MA), and alpha angle were obtained from the TEG tracing. TEG-R values were statistically higher during iNO treatment (7.75 +/- 3.34) when compared to the values before iNO (4.83 +/- 1.38) and the healthy controls (3.75 +/- 0.98). The alpha angle was lower in iNO treated infants at both periods (before iNO, 55.33 +/- 8.58; during iNO, 42.90 +/- 18.34) compared to the control group (64.95 +/- 6.88). MA values before iNO treatment were the lowest (44.43 +/- 14.09) and improved with the iNO treatment (48.40 +/- 9.49) despite still being lower compared to the controls (53.67 +/- 5.56). Conclusion: Both PPH and iNO may negatively effect in vitro coagulation tests. Therefore, newborns with PPH requiring iNO treatment should be closely monitored for coagulation problems.en_US
dc.identifier.doi10.1007/s00431-014-2325-3en_US
dc.identifier.endpage1385en_US
dc.identifier.issn0340-6199
dc.identifier.issn1432-1076
dc.identifier.issue10en_US
dc.identifier.pmid24791933en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1381en_US
dc.identifier.urihttps://doi.org/10.1007/s00431-014-2325-3
dc.identifier.urihttps://hdl.handle.net/11454/49647
dc.identifier.volume173en_US
dc.identifier.wosWOS:000342227700014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNitric oxideen_US
dc.subjectNewbornen_US
dc.subjectThromboelastogramen_US
dc.subjectCoagulationen_US
dc.subjectPulmonary hypertensionen_US
dc.titleThe effect of inhaled nitric oxide therapy on thromboelastogram in newborns with persistent pulmonary hypertensionen_US
dc.typeArticleen_US

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