Arsenic and Human Health: Genotoxicity, Epigenomic Effects, and Cancer Signaling

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dc.authoridShahzadi, Andleeb/0000-0003-2082-638X
dc.authoridBhat, Rouf Ahmad/0000-0002-0355-0062
dc.authoridmetin, mert/0000-0003-3476-1089
dc.authoridShahzadi, Andleeb/0000-0002-2774-2325
dc.authorscopusid7102666117
dc.authorscopusid57221783502
dc.authorscopusid16311550600
dc.authorscopusid56034867600
dc.authorscopusid57510662100
dc.authorscopusid57225918862
dc.authorscopusid55889428300
dc.authorwosidShahzadi, Andleeb/AAF-8237-2019
dc.authorwosidBhat, Rouf Ahmad/AFO-4271-2022
dc.contributor.authorOzturk, Munir
dc.contributor.authorMetin, Mert
dc.contributor.authorAltay, Volkan
dc.contributor.authorBhat, Rouf Ahmad
dc.contributor.authorEjaz, Mahnoor
dc.contributor.authorGul, Alvina
dc.contributor.authorUnal, Bengu Turkyilmaz
dc.date.accessioned2023-01-12T19:51:16Z
dc.date.available2023-01-12T19:51:16Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractArsenic is a well-known element because of its toxicity. Humans as well as plants and animals are negatively affected by its exposure. Some countries suffer from high levels of arsenic in their tap water and soils, which is considered a primary arsenic-linked risk factor for living beings. Humans generally get exposed to arsenic by contaminated drinking waters, resulting in many health problems, ranging from cancer to skin diseases. On the other hand, the FDA-certified drug arsenic trioxide provides solutions for various diseases, including several types of cancers. This issue emphasizes the importance of speciation of the metalloid elements in terms of impacts on health. When species get exposed to arsenic, it affects the cells altering their involvement. It can lead to abnormalities in inflammatory mechanisms and the immune system which contribute to the negative impacts generated on the body. The poisoning originating from arsenic gives rise to various biological signs on the body which can be useful for the diagnosis. It is important to find true biomarkers for the detection of arsenic poisoning. In view of its application in medicine and biology, studies on understanding the biological activity of arsenic have increased. In this review, we aim at summarizing the current state of knowledge of arsenic and the mechanism behind its toxicity including genotoxicity, oxidative insults, epigenomic changes, and alterations in cellular signaling.en_US
dc.identifier.doi10.1007/s12011-021-02719-w
dc.identifier.endpage1001en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue3en_US
dc.identifier.pmid33864199en_US
dc.identifier.scopus2-s2.0-85104751625en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage988en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-021-02719-w
dc.identifier.urihttps://hdl.handle.net/11454/76247
dc.identifier.volume200en_US
dc.identifier.wosWOS:000640726800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArsenicen_US
dc.subjectCanceren_US
dc.subjectCell signalingen_US
dc.subjectGenotoxicityen_US
dc.subjectHuman healthen_US
dc.subjectOxidative Dna-Damageen_US
dc.subjectHistone H3 Phosphoacetylationen_US
dc.subjectUnfolded Protein Responseen_US
dc.subjectGene-Expression Changesen_US
dc.subjectEarly-Life Exposureen_US
dc.subjectSodium Arseniteen_US
dc.subjectHeavy-Metalsen_US
dc.subjectMonomethylarsonous Aciden_US
dc.subjectInflammatory Responsesen_US
dc.subjectPotential Involvementen_US
dc.titleArsenic and Human Health: Genotoxicity, Epigenomic Effects, and Cancer Signalingen_US
dc.typeArticleen_US

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