The effectiveness of tetanus toxin on sciatic nerve regeneration: A preliminary experimental study in rats

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dc.contributor.authorGunay H.
dc.contributor.authorKucuk L.
dc.contributor.authorErbas O.
dc.contributor.authorAtamaz F.C.
dc.contributor.authorKucuk U.
dc.contributor.authorCoskunol E.
dc.date.accessioned2019-10-27T08:22:30Z
dc.date.available2019-10-27T08:22:30Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractObject The purpose was to investigate the effects of local tetanus toxin (TeTx) application on sciatic nerve regeneration following a rat model of transection injury. Methods After both sciatic nerves were transected and repaired with three epineural sutures, 12 male Wistar albino rats were divided into two groups. 0.25 ml (2.5 flocculation units) TeTx was injected into a piece of absorbable gelatin sponge in TeTx group. In controls, 0.25 ml saline injected. Assessments were performed by using climbing degrees, compound muscle action potentials (CMAPs) and histological parameters (axon number and axonal diameter) 12th week. Results CMAPs amplitudes were 11.6±4.7 mV and 1.4±1.3 mV in gastrocnemius and interdigital muscles in TeTx group (5.8±2.4 mV and 0.2±0.1 mV, P < 0.05). Climbing degrees were significantly different (61.6±1.7 vs. 38.3±2.6, P<0.05). Total axon numbers were higher (1341.1±57.3 vs. 877.5±34.9, P<0.05) and the mean axon diameter was smaller (4.2±2.1 vs. 2.5±1.9, P<0.05) in the TeTx group. Conclusion This preliminary study firstly demonstrated the effectiveness of TeTx on nerve repair in experimental sciatic rat model based on functional, electromyographic and histological parameters. © 2014 Wiley Periodicals, Inc. Microsurgery 34:384-389, 2014. © 2014 Wiley Periodicals, Inc.en_US
dc.identifier.doi10.1002/micr.22249en_US
dc.identifier.endpage389en_US
dc.identifier.issn0738-1085
dc.identifier.issue5en_US
dc.identifier.pmid24665036en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage384en_US
dc.identifier.urihttps://doi.org/10.1002/micr.22249
dc.identifier.urihttps://hdl.handle.net/11454/26263
dc.identifier.volume34en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Inc.en_US
dc.relation.ispartofMicrosurgeryen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleThe effectiveness of tetanus toxin on sciatic nerve regeneration: A preliminary experimental study in ratsen_US
dc.typeLetteren_US

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