Immunohistochemical Evaluation of Apoptosis and Multidrug Resistance- Related Markers in Gallbladder Dysplasia and Carcinoma

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dc.contributor.authorBaşak, Kayhan
dc.contributor.authorDemir, Derya
dc.contributor.authorKoçdoğan, Arzu Kaya
dc.contributor.authorOğuztüzün, Serpil
dc.date.accessioned2024-08-31T07:31:11Z
dc.date.available2024-08-31T07:31:11Z
dc.date.issued2022
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: The search for treatment success in gallbladder carcinomas, which is one of the tumors with the most aggressive course, poor prognosis, and tendency to show resistance to treatment, continues today. Treatments targeting pathways related to genetic changes de- tected in most solid tumors offer new hope in the treatment of these tumors. Some of these treatment modalities target apoptosis-related pathways, and mammalian target of rapamycin (mTOR), p38, Bcl-2, and caspase-3 are important components of this pathway. Methods: In the study, mTOR, caspase-3, p38, Bcl-2, LL-37, MDR1, multidrug resistance protein (MRP)1, MRP6, and MRP7 immunohistochemical staining were applied to paraffin blocks of 27 gallbladder cancer and 62 cases with gallbladder dysplasia. The immunohisto- chemically stained sections were evaluated and scored. Results: mTOR, p38, and caspase-3 expressions were found to be significantly increased in dysplasia and tumor groups, and in dysplastic and malignant cells. While there was no signifi- cant difference in the expression of MRP1 and MRP7, MRP6 was significantly overexpressed. Conclusion: In this study, increased expression of mTOR, p38, and caspase-3 in the dys- plastic and malignant cells of the gallbladder may show that it has a role in the carcinogenesis process in the gallbladder. The study also shows that MRP6 may also play a role in the devel- opment of drug resistance in gallbladder carcinoma.en_US
dc.identifier.doi10.14744/scie.2022.82712
dc.identifier.endpage428en_US
dc.identifier.issn2587-0998
dc.identifier.issn2587-1404
dc.identifier.issue4en_US
dc.identifier.startpage423en_US
dc.identifier.trdizinid1171579en_US
dc.identifier.urihttps://doi.org/10.14744/scie.2022.82712
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1171579
dc.identifier.urihttps://hdl.handle.net/11454/103344
dc.identifier.volume33en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofSouthern Clinics of Istanbul Eurasiaen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.titleImmunohistochemical Evaluation of Apoptosis and Multidrug Resistance- Related Markers in Gallbladder Dysplasia and Carcinomaen_US
dc.typeArticleen_US

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