A novel radiolabeled graft polymer: Investigation of the radiopharmaceutical potential using Albino Wistar rats

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dc.contributor.authorAvcibasi, Ugur
dc.contributor.authorAtes, Buket
dc.contributor.authorUnak, Perihan
dc.contributor.authorGumuser, Fikriye Gul
dc.contributor.authorGulcemal, Suleyman
dc.contributor.authorOl, Kevser Kusat
dc.contributor.authorTekin, Volkan
dc.date.accessioned2020-12-01T12:06:09Z
dc.date.available2020-12-01T12:06:09Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.descriptionUNAK, PERIHAN/0000-0002-5464-2987; Gulcemal, Suleyman/0000-0003-2738-3219en_US
dc.description.abstractFe3O4 magnetic graft-Lys-poly(HEMA) was synthesized, labeled with Tc-99m for the first time and its radiopharmaceutical potential was investigated using animal models in this study. Quality control procedures were carried out using thin layer radiochromatography. the labeling yield of radiolabeled polymer was found to be about 100%. Then, stability and lipophilicity were determined. the lipophilicity of Tc-99m labeled Fe3O4 graft-Lys-poly(HEMA) was found to be 3.77. the serum stability experiments demonstrated that approximately 100% of radiolabeled polymer existed as an intact complex in the rat serum within 240 min. Biodistribution of radiolabeled magnetic graft-Lys-poly(HEMA) was performed on female Albino Wistar rats by scintigraphy and biodistribution studies. High uptake was seen in the stomach, the pancreas, brain, ovarian, intestines and the breast.en_US
dc.description.sponsorshipManisa Celal Bayar University Coordination Unit of Scientific Research Projects (BAP) [2017-016]en_US
dc.description.sponsorshipThe authors are thankful for the financial support from the Manisa Celal Bayar University Coordination Unit of Scientific Research Projects (BAP) (Project number: 2017-016).en_US
dc.identifier.doi10.1016/j.apradiso.2019.108872en_US
dc.identifier.issn0969-8043
dc.identifier.pmid31470192en_US
dc.identifier.urihttps://doi.org/10.1016/j.apradiso.2019.108872
dc.identifier.urihttps://hdl.handle.net/11454/63165
dc.identifier.volume154en_US
dc.identifier.wosWOS:000498291900045en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofApplied Radiation and Isotopesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHEMAen_US
dc.subjectL-lysineen_US
dc.subjectGrafted polymeren_US
dc.subjectNanoparticleen_US
dc.subjectTc-99men_US
dc.titleA novel radiolabeled graft polymer: Investigation of the radiopharmaceutical potential using Albino Wistar ratsen_US
dc.typeArticleen_US

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