Dry Eye and Meibomian Gland Dysfunction in Neovascular Age-Related Macular Degeneration Patients Treated with Intravitreal Injections

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dc.authoridPalamar, Melis/0000-0002-2494-0131
dc.authorscopusid57194854896
dc.authorscopusid23989747000
dc.authorscopusid6506820542
dc.authorscopusid6603753886
dc.authorwosidPalamar, Melis/H-5903-2013
dc.contributor.authorKiyat, Pelin
dc.contributor.authorPalamar, Melis
dc.contributor.authorNalcaci, Serhad
dc.contributor.authorAkkin, Cezmi
dc.date.accessioned2023-01-12T20:16:55Z
dc.date.available2023-01-12T20:16:55Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractObjectives: To determine if patients treated with multiple intravitreal injections for neovascular age-related macular degeneration are more likely to suffer from dry eye and meibomian gland dysfunction. Materials and Methods: Sixty eyes of 30 patients were enrolled. One eye of each patient was treated with multiple monthly intravitreal injections for neovascular AMD (Group 1) and the fellow healthy eye received no treatment (Group 2). The presence of dry eye was evaluated using tear film break-up rime, Schirmer 1 test, the Oxford scale, and Ocular Surface Disease Index (OSDI). The loss rate of meibomian glands was evaluated by meibography and was graded and scored (meiboscore) from grade 0 (no lass of glands) to grade 3 (loss of >2/3 of total meibomian glands) for each eyelid. Results: Group I had lower mean Schirmer 1 and rear film break up-time measurements and higher mean OSDI score than Group 2, but the differences were not statistically significant (p=0.257, p=0.113, and p=0.212, respectively). Mean Oxford scale scores and meiboscore of the upper eyelids showed no statistically significant difference between the groups (p=0.594, p=0.663, respectively). The meiboscore of the lower eyelids was significantly higher in Group 1 (p=0.048). Conclusion: Multiple factors such as povidone-iodine and the preservatives in topical eye drops may cause inflammation leading to ocular surface damage in patients treated with multiple intravitreal injections. As the treatment requires repeated injections, exposure to these factors might worsen the ocular surface inflammation. The possibility of dry eye and meibomian gland dysfunction should be considered in these patients.en_US
dc.identifier.doi10.4274/tjo.galenos.2021.66168
dc.identifier.endpage161en_US
dc.identifier.issn1300-0659
dc.identifier.issn2147-2661
dc.identifier.issue3en_US
dc.identifier.pmid35769012en_US
dc.identifier.scopus2-s2.0-85133146832en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage157en_US
dc.identifier.urihttps://doi.org/10.4274/tjo.galenos.2021.66168
dc.identifier.urihttps://hdl.handle.net/11454/78793
dc.identifier.volume52en_US
dc.identifier.wosWOS:000821679600002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Ophthalmological Socen_US
dc.relation.ispartofTurk Oftalmoloji Dergisi-Turkish Journal of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntravitreal injectionen_US
dc.subjectneovascular age-related macular degenerationen_US
dc.subjectdry eyeen_US
dc.subjectmeibomian gland dysfunctionen_US
dc.subjectmeibographyen_US
dc.subjectOcular Surfaceen_US
dc.subjectInternational Workshopen_US
dc.subjectVisual Impairmenten_US
dc.subjectPovidone-Iodineen_US
dc.subjectMeibographyen_US
dc.subjectEndophthalmitisen_US
dc.subjectEpidemiologyen_US
dc.subjectDefinitionen_US
dc.subjectPrevalenceen_US
dc.subjectDiseaseen_US
dc.titleDry Eye and Meibomian Gland Dysfunction in Neovascular Age-Related Macular Degeneration Patients Treated with Intravitreal Injectionsen_US
dc.title.alternativeİntravitreal Enjeksiyon Tedavisi Alan Neovasküler Tip Yaşa Bağlı Maküla Dejeneresanslı Hastalarda Kuru Göz ve Meibomian Gland Disfonksiyonuen_US
dc.typeArticleen_US

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