Oxidative stress markers in saliva and periodontal disease status: Modulation during pregnancy and postpartum

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dc.contributor.authorGümüş P.
dc.contributor.authorEmingil G.
dc.contributor.authorÖztürk V.-O.
dc.contributor.authorBelibasakis G.N.
dc.contributor.authorBostanci N.
dc.date.accessioned2019-10-26T21:22:28Z
dc.date.available2019-10-26T21:22:28Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Periodontal diseases may affect local and systemic inflammation, and reactive oxygen species (ROS) levels. This systemic health burden could compromise the outcome of pregnancy in expectant mothers. The aim of the present study was to evaluate oxidative stress markers, including glutathione peroxidase (GPx), thiobarbituric acid-reactive substances (TBARS) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), and total bacterial loads in the saliva of pregnant and postpartum women, and to investigate their association with periodontal disease severity. Methods: A total of 187 women were originally recruited for this case-control study, assigned to the following groups a) pregnant group, b) postpartum group: the pregnant group re-evaluated 6 months after giving birth, c) control group: systemically healthy and non-pregnant women. The levels of the studied oxidative stress markers in saliva were measured by commercially available kits. Results: The levels of salivary 8-OHdG were significantly elevated in the pregnant, compared with the control group. Although salivary 8-OHdG levels slightly decreased after giving birth (postpartum group), the difference did not reach significance. In contrast, the activity of antioxidant enzyme GPx in saliva was significantly lower in the pregnant than the control group. Although no differences in lipid peroxidation (represented by TBARS) were observed between the pregnant and control groups, after giving birth TBARS levels were significantly lowered. Only in the postpartum and control groups did clinical measurements of periodontal disease severity correlate with oxidative stress markers. Interestingly, there were no such correlations with TBARS in the pregnant and postpartum groups. Conclusions: The present study shows changes in the oxidant/antioxidant balance in saliva during pregnancy and after birth, which may be affected by periodontal health status in the latter case. Whether this is associated with adverse pregnancy outcomes, or not, remains to be elucidated. Early identification of ROS markers in saliva may be of clinical value in the periodontal management of pregnant women. © 2015 Gümüş et al.en_US
dc.identifier.doi10.1186/s12879-015-1003-zen_US
dc.identifier.issn1471-2334
dc.identifier.issue1en_US
dc.identifier.pmid26152310en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1186/s12879-015-1003-z
dc.identifier.urihttps://hdl.handle.net/11454/16970
dc.identifier.volume15en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBioMed Central Ltd.en_US
dc.relation.ispartofBMC Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOxidative stressen_US
dc.subjectPeriodontal diseaseen_US
dc.subjectPregnancyen_US
dc.subjectReactive oxygen speciesen_US
dc.subjectSalivaen_US
dc.titleOxidative stress markers in saliva and periodontal disease status: Modulation during pregnancy and postpartumen_US
dc.typeArticleen_US

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