Pharmacologic and Regenerative Cell Therapy for Spinal Cord Injury: WFNS Spine Committee Recommendations

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dc.contributor.authorTakami, Toshihiro
dc.contributor.authorShimokawa, Nobuyuki
dc.contributor.authorParthiban, Jutty
dc.contributor.authorZileli, Mehmet
dc.contributor.authorAli, Sheena
dc.date.accessioned2021-05-03T20:36:44Z
dc.date.available2021-05-03T20:36:44Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractThis is a review article examining the pharmacologic and regenerative cell therapy for spinal cord injury. A literature search during last 10 years were conducted using key words. Case reports, experimental (nonhuman) studies, papers other than English language were excluded. Up-to-date information on the pharmacologic and regenerative cell therapy for spinal cord injury was reviewed and statements were produced to reach a consensus in 2 separate consensus meeting of WFNS Spine Committee. The statements were voted and reached a consensus using Delphi method. Pharmacologic and regenerative cell therapy for spinal cord injury have long been an interest of many experimental and clinical researches. Clinical studies with methylpredinisolone have not shown clear cut benefit. Other drugs such as Rho inhibitor, minocycline, riluzole, granulocyte colony-stimulating factor have also been tried without significant benefits. Regenerative cell therapy using different types of stem cells, different inoculation techniques, and scaffolds have undergone many trials highlighting the efficacies of cells and their limitations. This review article summarizes the current knowledge on pharmacologic and regenerative cell therapy for spinal cord injury. Unfortunately, there is a need for further experimental and human trials to recommend effective pharmacologic and regenerative cell therapy.en_US
dc.identifier.doi10.14245/ns.2040408.204en_US
dc.identifier.endpage796en_US
dc.identifier.issn2586-6583
dc.identifier.issn2586-6591
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85099436908en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage785en_US
dc.identifier.urihttps://doi.org/10.14245/ns.2040408.204
dc.identifier.urihttps://hdl.handle.net/11454/70172
dc.identifier.volume17en_US
dc.identifier.wosWOS:000604731600010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Spinal Neurosurgery Socen_US
dc.relation.ispartofNeurospineen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute spinal cord injuryen_US
dc.subjectMethylprednisoloneen_US
dc.subjectRiluzoleen_US
dc.subjectSpinal cord regenerationen_US
dc.subjectStem cellen_US
dc.titlePharmacologic and Regenerative Cell Therapy for Spinal Cord Injury: WFNS Spine Committee Recommendationsen_US
dc.typeReview Articleen_US

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