Elastic properties of the abdominal aorta in the children with bicuspid aortic valve: an observational study
Küçük Resim Yok
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Biküspit aortik kapaklı hastalarda aort anülüsü ve asendan aort anomalileri oldukça yaygın görülmektedir. Bu çalışmanın amacı biküspit aortik kapaklı çocuklarda abdominal aort sertliğini değerlendirmektir. Yöntemler: Enine kesitli gözlemsel olan bu çalışmada, kapak fonksiyonu normal veya hafif derecede yetmezliği olan 35 biküspit aortik kapaklı çocuk ile kontrol grubu olarak alınan sağlıklı 35 çocuk değerlendirildi. Tüm çocuklar transtorasik ekokardiyografi ile noninvaziv olarak değerlendirildi. Aort anülüsü ve abdominal aorta çapları ölçüldü. Bu ölçümlerde alınan veriler ile aortik gerilme (G), gerilme elastik modülü (Ep), diyastolik basınç ile normalleştirilmiş gerilme elastik modülü (Ep*), aortik sertlik indeksi (?SI) ve aortik esneklik (ES) hesaplandı. Verilerin istatistiksel değerlendirmesinde Student’s t-testi, Ki-kare testi, Pearson’s korelasyon analizi ve çoklu lineer regresyon analizi kullanıldı. Bulgular: Aort anülüs çapı kontrol grubuna göre anlamlı olarak geniş bulundu (p<0.05). Abdominal aortun sistolik ve diyastolik çapları açısından farklılık saptanmadı (p>0.05). Biküspit aortik kapaklı çocuklarda G (0.210±0.04/0.267±0.07, p<0.001) ve ES (1.04±0.2/1.4±0.4 $10^{-6}$ $cm^{2}$ $dyne^{-1}$, p<0.001) kontrol grubuna göre belirgin düşük; Ep (200±39/153±47 N/$m^{-2}$, p<0.001), Ep* (3.42±0.9/2.5±0.9, p<0.001) ve ?SI (1.1±0.3/0.84±0.3, p<0.001) ise belirgin olarak yüksek bulundu. Abdominal aort sistolik ve diyastolik çapları ile aortik elastisite parametreleri arasında ilişki saptanmadı (p>0.05). Sonuç: Biküspit aortik kapak, çocuklarda artmış aort sertliği ile ilişkilidir. Bununla birlikte abdominal aort elastisitesindeki bu bozulma aortik dilatasyondan kaynaklanmamaktadır. (Anadolu Kardiyol Derg 2012; 12: 413-9)
Objective: Abnormalities of the aortic root and ascending aorta are common in patients with a bicuspid aortic valve (BAV). the aim of this study was to evaluate the stiffness of the abdominal aorta in children with BAV. Methods: in this cross-sectional observational study, we evaluated 35 children with normally functioning or mildly regurgitant BAV and 35 healthy children as controls. All children were noninvasively evaluated with transthoracic echocardiography. Annulus of aorta and abdominal aorta diameters were measured. Aortic strain (S), pressure strain elastic modulus (Ep), pressure strain normalized by diastolic pressure (Ep*), aortic stiffness ? index (?SI) and, aortic distensibility (DIS) were calculated using the measured data. in evaluation of the data Student’s t-test, Chi-square test, Pearson’s correlation and multivariate linear regression analysis were used. Results: Diameter of the aortic annulus was found significantly larger in the children with BAV than the control group (p<0.05). the abdominal aorta systolic and diastolic diameters were similar in the two groups (p>0.05). the children with BAV exhibited significantly lower S (0.210±0.04/0.267±0.07, p<0.001) and DIS (1.04±0.2/1.4±0.4 $10^{-6}$ $cm^{2}$ $dyne^{-1}$, p<0.001); and higher Ep (200±39/153±47 N/$m^{-2}$, p<0.001), Ep* (3.42±0.9/2.5±0.9, p<0.001) and ?SI (1.1±0.3/0.84±0.3, p<0.001) than the control group. There was no correlation between the systolic and diastolic diameters of abdominal aorta and aortic elasticity parameters (p>0.05). Conclusion: Bicuspid aortic valve is associated with an increased abdominal aortic stiffness in children. However, impaired abdominal aortic elasticity is not due to abdominal aortic dilatation. These findings require validation by further studies. (Anadolu Kardiyol Derg 2012; 12: 413-9)
Objective: Abnormalities of the aortic root and ascending aorta are common in patients with a bicuspid aortic valve (BAV). the aim of this study was to evaluate the stiffness of the abdominal aorta in children with BAV. Methods: in this cross-sectional observational study, we evaluated 35 children with normally functioning or mildly regurgitant BAV and 35 healthy children as controls. All children were noninvasively evaluated with transthoracic echocardiography. Annulus of aorta and abdominal aorta diameters were measured. Aortic strain (S), pressure strain elastic modulus (Ep), pressure strain normalized by diastolic pressure (Ep*), aortic stiffness ? index (?SI) and, aortic distensibility (DIS) were calculated using the measured data. in evaluation of the data Student’s t-test, Chi-square test, Pearson’s correlation and multivariate linear regression analysis were used. Results: Diameter of the aortic annulus was found significantly larger in the children with BAV than the control group (p<0.05). the abdominal aorta systolic and diastolic diameters were similar in the two groups (p>0.05). the children with BAV exhibited significantly lower S (0.210±0.04/0.267±0.07, p<0.001) and DIS (1.04±0.2/1.4±0.4 $10^{-6}$ $cm^{2}$ $dyne^{-1}$, p<0.001); and higher Ep (200±39/153±47 N/$m^{-2}$, p<0.001), Ep* (3.42±0.9/2.5±0.9, p<0.001) and ?SI (1.1±0.3/0.84±0.3, p<0.001) than the control group. There was no correlation between the systolic and diastolic diameters of abdominal aorta and aortic elasticity parameters (p>0.05). Conclusion: Bicuspid aortic valve is associated with an increased abdominal aortic stiffness in children. However, impaired abdominal aortic elasticity is not due to abdominal aortic dilatation. These findings require validation by further studies. (Anadolu Kardiyol Derg 2012; 12: 413-9)
Açıklama
Anahtar Kelimeler
Kalp ve Kalp Damar Sistemi
Kaynak
Anadolu Kardiyoloji Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
12
Sayı
5
