Nicotine interacts with sex in affecting rat choice between 'look-out' and 'navigational' cognitive styles in the morris water maze place learning task

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dc.contributor.authorKanit L.
dc.contributor.authorTaşkiran D.
dc.contributor.authorFuredy J.J.
dc.contributor.authorKulali B.
dc.contributor.authorMcDonald R.
dc.contributor.authorPögün Ş.
dc.date.accessioned2019-10-27T09:00:34Z
dc.date.available2019-10-27T09:00:34Z
dc.date.issued1998
dc.departmentEge Üniversitesien_US
dc.description.abstractThe effect of sex and nicotine on cognitive style was examined in rats using a water maze task that allows differentiation between cognitive ability and style. During the 12-day acquisition period with the platform in the same location (either visible or hidden) there were no effects or interactions attributable to nicotine and sex, either in terms of learning rate or asymptotic latency. On the final test day the platform was visible and shifted in its location, and on the first trial the new location was proximal to the rats starting position, in contrast to the more distal location of the platform during the previous acquisition days. This platform relocation presented the rats with a choice between two competing cognitive styles: using local visual (look-out) cues vs. navigational cues. Performance on the test day yielded a nicotine x sex interaction, such that only saline-treated female rats showed a clear preference for the perceptual-proximal look-out cognitive style by swimming straight to the newly-relocated visible platform with mean escape latency that approximated the limits of swimming speed. The other three groups did not differ from each other, and preferred navigational cues. The results show that male and female rats use different strategies in problem solving, and that nicotine shifts the female pattern to that of the male.en_US
dc.description.sponsorshipLütfiye Kanıt was awarded the “Young Investigator Award: 1st prize” in the 1997 National Congress of Physiological Sciences, Adana, Turkey, with her contribution in this study. Supported by Grant SBAG 15/3 from the Scientific and Technical Research Council of Turkey (TUBITAK). --en_US
dc.identifier.doi10.1016/S0361-9230(98)00008-2en_US
dc.identifier.endpage445en_US
dc.identifier.issn0361-9230
dc.identifier.issue5en_US
dc.identifier.pmid9739007en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage441en_US
dc.identifier.urihttps://doi.org/10.1016/S0361-9230(98)00008-2
dc.identifier.urihttps://hdl.handle.net/11454/28087
dc.identifier.volume46en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofBrain Research Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCognitive strategiesen_US
dc.subjectNicotineen_US
dc.subjectPlace learningen_US
dc.subjectSex differencesen_US
dc.subjectWater mazeen_US
dc.titleNicotine interacts with sex in affecting rat choice between 'look-out' and 'navigational' cognitive styles in the morris water maze place learning tasken_US
dc.typeArticleen_US

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