Effect of Aortic Valve Opening Pattern on Endothelial Function After Continuous-Flow Left Ventricular Assist Device Implantation

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dc.authorscopusid57218190132
dc.authorscopusid57211015002
dc.authorscopusid23568467100
dc.authorscopusid7004155093
dc.authorscopusid6603075845
dc.authorscopusid6603386914
dc.authorscopusid6602803130
dc.contributor.authorKaya, E.
dc.contributor.authorKocabaş, U.
dc.contributor.authorŞimşek, E.
dc.contributor.authorNalbantgil, S.
dc.contributor.authorEngin, Ç.
dc.contributor.authorÖzbaran, M.
dc.contributor.authorAkilli, A.
dc.date.accessioned2024-08-25T18:38:38Z
dc.date.available2024-08-25T18:38:38Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractThis study aimed to evaluate the effects of aortic valve opening patterns on endothelial functions in patients undergoing continuous-flow left ventricular assist device (CF-LVAD) implantation. This study included 43 patients who underwent CF-LVAD implantation and 35 patients with heart failure reduced ejection fraction (HFrEF; control group). The CF-LVAD group was divided into three subgroups based on aortic valve opening patterns: open with each beat, intermittently opening, and not opening groups. Flow-mediated dilatation (FMD) and pulsatility index (PI) were compared before and 3 months after CF-LVAD implantation. Cardiopulmonary exercise test (CPET) and 6 minute walk test (6-MWT) scores were measured at baseline and follow-up in the CF-LVAD group. The mean FMD and PI of patients in the CF-LVAD group reduced 3 months after implantation. Patients with intermittently opening and not opening aortic valves had worse endothelial function at follow-up. Before and 3 months after implantation FMD% did not significantly differ in patients whose aortic valves were open with each beat (4.72 ± 1.06% vs. 4.67 ± 1.16%, p = 0.135). Pulsatility index changes paralleled FMD changes. Cardiopulmonary exercise test and 6-MWT scores improved after implantation but without significant differences between subgroups. Maintaining normal aortic valve function after CF-LVAD implantation may reduce endothelial dysfunction; however, larger studies are needed for long-term clinical effects. © 2023 Lippincott Williams and Wilkins. All rights reserved.en_US
dc.identifier.doi10.1097/MAT.0000000000002025
dc.identifier.endpageE436en_US
dc.identifier.issn1058-2916
dc.identifier.issue10en_US
dc.identifier.pmid37773149en_US
dc.identifier.scopus2-s2.0-85174269880en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageE429en_US
dc.identifier.urihttps://doi.org/10.1097/MAT.0000000000002025
dc.identifier.urihttps://hdl.handle.net/11454/101099
dc.identifier.volume69en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams and Wilkinsen_US
dc.relation.ispartofASAIO Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectaortic valveen_US
dc.subjectcontinuous-flow left ventricular assist deviceen_US
dc.subjectendothelial dysfunctionen_US
dc.subjectflow-mediated dilatationen_US
dc.subjectheart failureen_US
dc.subjectheart failure reduced ejection fractionen_US
dc.subjectpulsatility indexen_US
dc.subjectBlood vesselsen_US
dc.subjectCardiologyen_US
dc.subjectFailure (mechanical)en_US
dc.subjectFiber optic sensorsen_US
dc.subjectAortic valvesen_US
dc.subjectContinuous-flowen_US
dc.subjectContinuous-flow leave ventricular assist deviceen_US
dc.subjectEjection fractionen_US
dc.subjectEndothelial dysfunctionen_US
dc.subjectFlow-mediated dilatationen_US
dc.subjectHeart failureen_US
dc.subjectHeart failure reduced ejection fractionen_US
dc.subjectPulsatility indexen_US
dc.subjectLeft ventricular assist devicesen_US
dc.titleEffect of Aortic Valve Opening Pattern on Endothelial Function After Continuous-Flow Left Ventricular Assist Device Implantationen_US
dc.typeArticleen_US

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