Abnormal white matter integrity and impairment of cognitive abilities in adolescent inhalant abusers

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dc.contributor.authorYuncu, Zeki
dc.contributor.authorZorlu, Nabi
dc.contributor.authorSaatcioglu, Hozan
dc.contributor.authorBasay, Burge
dc.contributor.authorBasay, Omer
dc.contributor.authorZorlu, Pelin Kurtgoz
dc.contributor.authorKitis, Omer
dc.contributor.authorGelal, Fazil
dc.date.accessioned2019-10-27T22:30:29Z
dc.date.available2019-10-27T22:30:29Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractInhalant abuse represents a major health problem especially among adolescents and young adults. However, less is known about white matter (WM) microstructure in adolescent inhalant abusers. In the present study, we used diffusion tensor imaging (DTI) to study WM changes in adolescent inhalant abusers compared with healthy controls. We also tested whether there was any relationship between WM integrity and neuropsychological measures in adolescent inhalant abusers. The study included 19 adolescent inhalant abusers and 19 healthy control subjects. Whole brain analysis of WM microstructure was performed using tract-based spatial statistics (TBSS) to detect abnormal WM regions between groups. Wisconsin card sorting test (WCST) and Stroop test were used to measure neuropsychological performance. We found that adolescent inhalant abuser group had significantly higher axial diffusivity (AD) values in left parietal, occipital and temporal WM than in healthy control group. Inhalant abuser and control groups did not differ significantly on fractional anisotropy (FA) and radial diffusivity (RD) values. Adolescent inhalant abusers showed worse performance when compared with control group in WCST and Stroop test. There was no significant correlation of AD values in significant clusters with neuropsychological test performances within the two groups. We only found discrete impairments in neuropsychological test performance and WM integrity in adolescent inhalant abusers compared with healthy control subjects and we were not able to demonstrate a direct correlation between WM alterations and neurocognitive performance. Future work is required to longitudinally evaluate brain abnormalities through methods assessing brain structure, function and connectivity. (C) 2014 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipEge University Science and Technology Application and Research CenterEge University [09/EGEBAM/001]en_US
dc.description.sponsorshipThis research was funded by Ege University Science and Technology Application and Research Center (grant number 09/EGEBAM/001) which had no role in the design of the study, collection and analysis of data and decision to publish.en_US
dc.identifier.doi10.1016/j.ntt.2014.11.009en_US
dc.identifier.endpage95en_US
dc.identifier.issn0892-0362
dc.identifier.issn1872-9738
dc.identifier.pmid25479538en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://doi.org/10.1016/j.ntt.2014.11.009
dc.identifier.urihttps://hdl.handle.net/11454/51242
dc.identifier.volume47en_US
dc.identifier.wosWOS:000348955000010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofNeurotoxicology and Teratologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInhalant abuseen_US
dc.subjectDiffusion tensor imagingen_US
dc.subjectTract-based spatial statisticsen_US
dc.subjectWhite matteren_US
dc.subjectNeuropsychologyen_US
dc.titleAbnormal white matter integrity and impairment of cognitive abilities in adolescent inhalant abusersen_US
dc.typeArticleen_US

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