Application of Biofunctionalized Magnetic Nanoparticles Based-Sensing in Abused Drugs Diagnostics

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dc.contributor.authorSanli, Serdar
dc.contributor.authorGhorbani-Zamani, Faezeh
dc.contributor.authorMoulahoum, Hichem
dc.contributor.authorGumus, Zinar Pinar
dc.contributor.authorCoskunol, Hakan
dc.contributor.authorDemirkol, Dilek Odaci
dc.contributor.authorTimur, Suna
dc.date.accessioned2020-12-01T12:04:58Z
dc.date.available2020-12-01T12:04:58Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractReal-time detection of substance use is an approach of high interest leading to the optimization of behavioral interventions and drug abuse intervention. the current methods in use suffer many limitations and need high logistical and laboratory requirements. Biosensors have shown a great potential in overcoming these limitations. in the present study, the electrochemical biosensor composed of a screen-printed electrode (SPE) was designed for the detection of synthetic cannabinoid (SC). Antibody-immobilized magnetic nanoparticles were also used to create a surface on the transducer with magnetic interactions in order to detect JWH-073 as a SC model. the use of immobilized magnetic nanoparticles to create working surfaces makes the electrode a reusable SPE which can be reutilized after the cleansing. To examine and observe any possible changes on the surface due to its interaction with the analyte, different electrochemical techniques such as differential pulse voltammetry, cyclic voltammetry, and electrochemical impedance spectrometry were applied. Based on the obtained results, the linearity of the biosensor was found between 5 and 400 ng/mL, and the detection limit was calculated as 22 ng/mL (n = 6) using the 3 Sb/m formula. the biosensor functionality was studied in the presence of some related interferents that showed lower responses than JWH-073, thus demonstrating the good selectivity of the prepared biosensor. Finally, the sensory platform was used to test synthetic urine sample, and the results were compared with obtained results from liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF/MS), which showed that the proposed method could be utilized to identify abuse drugs.en_US
dc.description.sponsorshipRepublic of Turkey, Ministry of DevelopmentTurkiye Cumhuriyeti Kalkinma Bakanligi [2016K121190]; Ege University, Aliye USTER FoundationEge Universityen_US
dc.description.sponsorshipThis work was funded by Republic of Turkey, Ministry of Development (Project Grant No: 2016K121190). SEM and Chromatographic analyses were performed at EGE MATAL (Ege University/Izmir). Ege University, Aliye USTER Foundation is also acknowledged for the financial support.en_US
dc.identifier.doi10.1021/acs.analchem.9b04025en_US
dc.identifier.endpage1040en_US
dc.identifier.issn0003-2700
dc.identifier.issn1520-6882
dc.identifier.issue1en_US
dc.identifier.pmid31800231en_US
dc.identifier.scopus2-s2.0-85077727294en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1033en_US
dc.identifier.urihttps://doi.org/10.1021/acs.analchem.9b04025
dc.identifier.urihttps://hdl.handle.net/11454/62828
dc.identifier.volume92en_US
dc.identifier.wosWOS:000506719400097en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofAnalytical Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleApplication of Biofunctionalized Magnetic Nanoparticles Based-Sensing in Abused Drugs Diagnosticsen_US
dc.typeArticleen_US

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