Fc? receptor polymorphisms in patients with transient hypogammaglobulinemia of infancy presenting with mild and severe infections
Küçük Resim Yok
Tarih
2015
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Allergy and Immunology Society of Thailand
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Patients with transient hypogammaglobulinaemia of infancy (THI) may have mild infections or be asymptomatic. About 20% of THI patients have very severe and recurrent infections and receive intravenous immunoglobulins (IVIg) for replacement therapy and infection prophylaxis. It is still not clear why some THI patients are severely symptomatic; it has been suggested that there might be additional immunologic or environmental factors or other co-morbidities. Objective: As an immunological factor, Fc? receptor polymorphisms (H/H-131, H/R-131 and R/R-131 for Fc?IIa; V/V-158, V/F-158 and F/F- 158 for Fc?RIIIa; NA1/NA1, NA1/NA2 and NA2/NA2 for Fc?RIIIb) were analysed in THI patients who had very severe infections and need hospitalisation (treated with IVIg) (n:18) and in THI patients who were asymptomatic or had mild infections (treated with antibiotics or received no medication) (n:25). Results: Genotypic distributions between two groups did not deviate significantly from the Hardy-Weinberg equilibrium expectations (p > 0.05) and odds ratios for “disease risk estimate” did not show any dominance for any genotype. Allele frequencies did not show any significant difference between the two groups (p >0.05). The number of infections per year for each Fc? receptor genotype was not significantly different between both groups. Conclusion: There is no association between the heterogeneous clinical picture of THI patients and Fc? receptor gene polymorphisms. © 2009 is a Digital Portal of health science journals in Thailand.
Açıklama
Anahtar Kelimeler
Fc? receptor polymorphisms, Infection, IVIg, Transient hypogammaglobulinaemia of infancy
Kaynak
Asian Pacific Journal of Allergy and Immunology
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
33
Sayı
4
