Changes in blood biochemistry thrombosis parameters 24 hours after stent-assisted endovascular treatment of intracranial aneurysms

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dc.contributor.authorCinar, Celal
dc.contributor.authorOran, Ismail
dc.contributor.authorOzdemir, Halil Ibrahim
dc.contributor.authorKusbeci, Mahmut
dc.contributor.authorKavakli, Ramazan Kaan
dc.contributor.authorTobu, Mahmut
dc.contributor.authorParildar, Zuhal
dc.date.accessioned2024-08-31T07:46:59Z
dc.date.available2024-08-31T07:46:59Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground and purpose This study aims to elucidate the early changes in blood biochemistry thrombosis parameters following stent-assisted endovascular treatment of intracranial aneurysms.Methods Consecutive patients with unruptured aneurysms undergoing stent implantation during endovascular treatment were included in this prospective study with approval from the local ethics committee. Blood samples were collected immediately before and 24 h after the procedure for biochemical analysis, including basic thrombosis indicators, bleeding tests, and a complete blood count.Results The study included 80 patients (60 women, 20 men) with 134 aneurysms. A total of 135 stents (110 flow-diverting, 25 standard) were used. Additionally, intrasaccular coiling was utilized in 28 aneurysms among 27 patients. Following the procedure, there was a significant decrease in activated partial thromboplastin time, fibrinogen, hemoglobin, and platelet levels, and a significant increase in prothrombin time, D-dimer, von Willebrand factor (vWF) activity/antigen ratio, and leukocyte levels in all patients. Correlation analyses revealed significant positive associations between platelet and fibrinogen levels, and a negative association between D-dimer and fibrinogen levels in the coil (-) group. Additionally, there was a significant negative correlation between aneurysm volume and vWF activity/antigen ratio, and procedure duration and thrombocyte count, while a positive association was found between aneurysm number and leukocyte count in the coil (-) group.Conclusions Analysis of blood chemistry alterations indicates that intravascular thrombosis occurs in the intracranial circulation following stent-assisted endovascular treatment of intracranial aneurysms. This thrombotic process is more pronounced in patients whose aneurysms were left open (i.e. flow-diverting stent alone).en_US
dc.description.sponsorshipScientific Research Project Office of Ege University [BAP-22633]en_US
dc.description.sponsorshipThe authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article:The study was supported by the Scientific Research Project Office of Ege University (Project Number: BAP-22633).en_US
dc.identifier.doi10.1177/15910199241272522
dc.identifier.issn1591-0199
dc.identifier.issn2385-2011
dc.identifier.pmid39113620en_US
dc.identifier.scopus2-s2.0-85200756985en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1177/15910199241272522
dc.identifier.urihttps://hdl.handle.net/11454/104272
dc.identifier.wosWOS:001287284700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofInterventional Neuroradiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectAneurysmen_US
dc.subjectStenten_US
dc.subjectFlow-Diverting Stenten_US
dc.subjectComplicationen_US
dc.subjectThrombosisen_US
dc.titleChanges in blood biochemistry thrombosis parameters 24 hours after stent-assisted endovascular treatment of intracranial aneurysmsen_US
dc.typeArticleen_US

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