Fas, Fas Ligand, and Vitamin D Receptor FokI Gene Polymorphisms in Patients with Type 1 Diabetes Mellitus in the Aegean Region of Turkey

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dc.contributor.authorSahin, Serap Baydur
dc.contributor.authorCetinkalp, Sevki
dc.contributor.authorErdogan, Mehmet
dc.contributor.authorYilmaz, Candeger
dc.contributor.authorBerdeli, Afig
dc.date.accessioned2019-10-27T21:41:04Z
dc.date.available2019-10-27T21:41:04Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: Several gene polymorphisms have been reported to be associated with the risk of developing type 1 diabetes. Among them, the human leukocyte antigen locus is the strongest genetic determinant. To identify additional genetic markers, we aimed to evaluate the relationship between the Fas, Fas ligand (FasL), and vitamin D receptor (VDR) FokI gene polymorphisms and the susceptibility to type 1 diabetes in the Aegean region of Turkey. Materials and Methods: Eighty-five patients with type 1 diabetes and 80 healthy controls were included in this study. The Fas -670A/G, FasL -843C/T, and VDR FokI gene polymorphisms were evaluated using the polymerase chain reaction-restriction fragment length polymorphism method. Results: The evaluation of the Fas genotype and the gene allele frequency did not show statistically significant differences between the patient and control group. Distribution of the FasL genotype differed significantly between patients and controls. The distribution of the VDR FokI genotype and allele frequencies differed significantly between the patients and controls. Individuals with type 1 diabetes presented less commonly with the FokI f allele. Conclusions: Our findings suggest that the FasL -843C/T and VDR FokI gene polymorphisms are associated with type 1 diabetes in the Agean region of Turkey; however, the Fas -670A/G gene polymorphism is not.en_US
dc.identifier.doi10.1089/gtmb.2012.0173en_US
dc.identifier.endpage1183en_US
dc.identifier.issn1945-0265
dc.identifier.issue10en_US
dc.identifier.pmid22946667en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1179en_US
dc.identifier.urihttps://doi.org/10.1089/gtmb.2012.0173
dc.identifier.urihttps://hdl.handle.net/11454/46528
dc.identifier.volume16en_US
dc.identifier.wosWOS:000309957500005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert Incen_US
dc.relation.ispartofGenetic Testing and Molecular Biomarkersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleFas, Fas Ligand, and Vitamin D Receptor FokI Gene Polymorphisms in Patients with Type 1 Diabetes Mellitus in the Aegean Region of Turkeyen_US
dc.typeArticleen_US

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