Optimization of prednisolone acetate-loaded chitosan microspheres using a 2(3) factorial design for preventing restenosis

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dc.contributor.authorSarisozen, Can
dc.contributor.authorArica, Betuel
dc.contributor.authorOrman, Mehmet N.
dc.contributor.authorHincal, A. Atilla
dc.contributor.authorCalis, Sema
dc.date.accessioned2019-10-27T21:18:15Z
dc.date.available2019-10-27T21:18:15Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractPrednisolone acetate (PA)-loaded microspheres were prepared by the spray-drying technique using different polymer (1% and 2%) and drug concentrations (10% and 20%). To obtain the optimum formulation, a three-factor two-level (2<SU3</SU) design was employed. The independent variables were polymer molecular weight, polymer concentration, and theoretical drug loading. Responses were the particle size, percentage of encapsulation efficiency, and the t(50%) release. The best formulation was prepared with 20% of PA and 1% of chitosan with medium molecular weight showing relative good yield of production (48.0 +/- 6.7%) and encapsulation efficiency (45.7 +/- 0.3%), and released the drug at a constant rate in 11 days.</.en_US
dc.description.sponsorshipHacettepe University Research FundHacettepe University [0302301007]en_US
dc.description.sponsorshipThis study was supported by Hacettepe University Research Fund (Project No: 0302301007). The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.en_US
dc.identifier.doi10.3109/10717541003667780en_US
dc.identifier.endpage186en_US
dc.identifier.issn1071-7544
dc.identifier.issue3en_US
dc.identifier.pmid20196705en_US
dc.identifier.startpage178en_US
dc.identifier.urihttps://doi.org/10.3109/10717541003667780
dc.identifier.urihttps://hdl.handle.net/11454/43949
dc.identifier.volume17en_US
dc.identifier.wosWOS:000275655800011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofDrug Deliveryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMicrospheresen_US
dc.subjectprednisolone acetateen_US
dc.subjectchitosanen_US
dc.subjectfactorial designen_US
dc.subjectspray-dryingen_US
dc.titleOptimization of prednisolone acetate-loaded chitosan microspheres using a 2(3) factorial design for preventing restenosisen_US
dc.typeArticleen_US

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