Epidural lornoxicam administration - innocent

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dc.contributor.authorCanduz, Basak
dc.contributor.authorAktug, Huseyin
dc.contributor.authorMavioglu, Oemuer
dc.contributor.authorErkin, Yueksel
dc.contributor.authorYilmaz, Ozlem
dc.contributor.authorUyanikgil, Yigit
dc.contributor.authorKorkmaz, Huelya
dc.contributor.authorBaka, Meral
dc.date.accessioned2019-10-27T20:01:27Z
dc.date.available2019-10-27T20:01:27Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractWe aimed to determine the analgesic efficacy and clincial or histopathological neurotoxicity of epidural single-dose lornoxicam. Caudal epidural catheters were inserted into 28 rabbits, divided into four groups, on day 1. Pain latency and degree of motor and sensory loss for each animal for different concentrations of lornoxicam were determined on day 2. All animals were sacrificed on day 3 and laminectomy was performed. Five-mu m thick sections of spinal cord, obtained from two segments caudal and two segments rostral from tip of the catheter, were fixed and were stained and evaluated by light microscopy. Lornoxicam produced dose-dependent analgesia (increase in pain latency), brief, mild and reversible motor and sensory block, and histopathological signs of neurotoxicity. Clinical application of epidural lornoxicam should proceed with caution. (c) 2006 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.jocn.2006.10.006en_US
dc.identifier.endpage974en_US
dc.identifier.issn0967-5868
dc.identifier.issn1532-2653
dc.identifier.issue10en_US
dc.identifier.pmid17823047en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage968en_US
dc.identifier.urihttps://doi.org/10.1016/j.jocn.2006.10.006
dc.identifier.urihttps://hdl.handle.net/11454/41260
dc.identifier.volume14en_US
dc.identifier.wosWOS:000249938200010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofJournal of Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectepidural lornoxicamen_US
dc.subjectraten_US
dc.subjectneurotoxicityen_US
dc.subjecthistopathologyen_US
dc.titleEpidural lornoxicam administration - innocenten_US
dc.typeArticleen_US

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