Biomarker Detection in Early Diagnosis of Cancer: Recent Achievements in Point-of-Care Devices Based on Paper Microfluidics

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dc.authoridAşcı Erkoçyiğit, Bilge/0000-0003-1567-9899
dc.authoridYardim, Aysenur/0000-0003-4762-7292
dc.authorscopusid58161755500
dc.authorscopusid58161755600
dc.authorscopusid57221691845
dc.authorscopusid57564391200
dc.authorscopusid6701638388
dc.authorwosidAşcı Erkoçyiğit, Bilge/HZL-1792-2023
dc.authorwosidÖzufuklar, Özge/HZL-5399-2023
dc.contributor.authorErkocyigit, Bilge Asci
dc.contributor.authorOzufuklar, Ozge
dc.contributor.authorYardim, Aysenur
dc.contributor.authorCelik, Emine Guler
dc.contributor.authorTimur, Suna
dc.date.accessioned2024-08-25T18:53:04Z
dc.date.available2024-08-25T18:53:04Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractMicrofluidics is very crucial in lab-on-a-chip systems for carrying out operations in a large-scale laboratory environment on a single chip. Microfluidic systems are miniaturized devices in which the fluid behavior and control can be manipulated on a small platform, with surface forces on the platform being greater than volumetric forces depending on the test method used. In recent years, paper-based microfluidic analytical devices (mu PADs) have been developed to be used in point-of-care (POC) technologies. mu PADs have numerous advantages, including ease of use, low cost, capillary action liquid transfer without the need for power, the ability to store reagents in active form in the fiber network, and the capability to perform multiple tests using various measurement techniques. These benefits are critical in the advancement of paper-based microfluidics in the fields of disease diagnosis, drug application, and environment and food safety. Cancer is one of the most critical diseases for early detection all around the world. Detecting cancer-specific biomarkers provides significant data for both early diagnosis and controlling the disease progression. mu PADs for cancer biomarker detection hold great promise for improving cure rates, quality of life, and minimizing treatment costs. Although various types of bioanalytical platforms are available for the detection of cancer biomarkers, there are limited studies and critical reviews on paper-based microfluidic platforms in the literature. Hence, this article aims to draw attention to these gaps in the literature as well as the features that future platforms should have.en_US
dc.identifier.doi10.3390/bios13030387
dc.identifier.issn2079-6374
dc.identifier.issue3en_US
dc.identifier.pmid36979600en_US
dc.identifier.scopus2-s2.0-85151109114en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/bios13030387
dc.identifier.urihttps://hdl.handle.net/11454/102963
dc.identifier.volume13en_US
dc.identifier.wosWOS:000968424900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofBiosensors-Baselen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectpaper-based microfluidicsen_US
dc.subjectbiomarker detectionen_US
dc.subjectcancer biomarkersen_US
dc.subjectin vitro diagnosticsen_US
dc.subjectpoint-of-care testing (POCT)en_US
dc.subjectLow-Costen_US
dc.subjectMultiplexed Detectionen_US
dc.subjectSensitive Detectionen_US
dc.subjectElectrochemical Biosensoren_US
dc.subjectNano-Inken_US
dc.subjectImmunodeviceen_US
dc.subjectPlatformen_US
dc.subjectWaxen_US
dc.subjectImmunoassayen_US
dc.subjectFabricationen_US
dc.titleBiomarker Detection in Early Diagnosis of Cancer: Recent Achievements in Point-of-Care Devices Based on Paper Microfluidicsen_US
dc.typeReview Articleen_US

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