Effect of endovascular treatment on nitric oxide and renal function in Takayasu's arteritis with renovascular hypertension

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dc.contributor.authorParildar, Z
dc.contributor.authorGulter, C
dc.contributor.authorParildar, M
dc.contributor.authorOran, I
dc.contributor.authorErdener, D
dc.contributor.authorMemis, A
dc.date.accessioned2019-10-27T18:18:43Z
dc.date.available2019-10-27T18:18:43Z
dc.date.issued2002
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Renal involvement in Takayasu's arteritis (TA) effects the disease outcome and endovascular treatment is an effective treatment of choice. We investigated nitric oxide (NO) levels and the effect of endovascular treatment in renovascular hypertensive TA patients. Methods: In five hypertensive patients with renal artery stenosis due to TA, serum creatinine, nitrite, nitrate; urinary microalbumin, nitrite, nitrate measurements and blood pressures were recorded at entry and after 24 h and 6 weeks of endovascular treatment. Results: Serum NO levels were higher in patients than controls (p = 0.008). Serum and urine NO levels increased 24 h after the treatment and decreased after 6 weeks (p = 0.015; p = 0.01, respectively). After the treatment blood pressures decreased. Urinary microalbumin excretions increased after the intervention (p = 0.02) and returned to normal in patients 1 and 4, and decreased in the other:. There were no significant differences in estimated glomerular filtration rate (EGFR), serum creatinine, urinary sodium and potassium levels. Conclusion: Increased NO secretion in these patients may contribute to improve the prognosis of renal function through its vasodilator and antiproliferative activities possibly by counterbalancing the excessive vasoconstrictor actions. Endovascular treatment causes a dilatation-induced shear stress that may be responsible for the increased NO release, which in turn leads to the rapid hypotensive response. Copyright (C) 2002 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000063514en_US
dc.identifier.endpage96en_US
dc.identifier.issn1420-4096
dc.identifier.issue2en_US
dc.identifier.pmid12077490en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage91en_US
dc.identifier.urihttps://doi.org/10.1159/000063514
dc.identifier.urihttps://hdl.handle.net/11454/35533
dc.identifier.volume25en_US
dc.identifier.wosWOS:000176952200005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofKidney & Blood Pressure Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectnitric oxideen_US
dc.subjectTakayasu's arteritisen_US
dc.subjectrenovascular hypertensionen_US
dc.subjectendovascular treatmenten_US
dc.titleEffect of endovascular treatment on nitric oxide and renal function in Takayasu's arteritis with renovascular hypertensionen_US
dc.typeArticleen_US

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