Successful Treatment of a Child with Hemoglobin Hammersmith with Hematopoietic Stem Cell Transplantation

Basit Öğe Kaydı
dc.authoridGULEN, HUSEYIN/0000-0002-5374-4957
dc.authoridOymak, Yesim/0000-0002-6908-8309
dc.authoridTUREDI YILDIRIM, AYSEN/0000-0002-4451-5108
dc.authoridozek, gulcihan/0000-0001-7111-4214
dc.authorscopusid51162360700
dc.authorscopusid6603211104
dc.authorscopusid58297686400
dc.authorscopusid55239904000
dc.authorscopusid24725291500
dc.authorscopusid23472577300
dc.authorscopusid6602888517
dc.authorwosidGULEN, HUSEYIN/C-2969-2013
dc.contributor.authorTüredi Yıldırım, Ayşen
dc.contributor.authorGülen, Hüseyin
dc.contributor.authorTürkmen, Hulya
dc.contributor.authorÖzek, Gülcihan
dc.contributor.authorOymak, Yeşim
dc.contributor.authorDurmaz, Burak
dc.contributor.authorKaraca, Emin
dc.date.accessioned2024-08-25T18:36:12Z
dc.date.available2024-08-25T18:36:12Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractHemoglobin (Hb) Hammersmith, formed by serine substitution for phenylalanine at residue 42 in the beta-globin chain, is a very rare variant of unstable hemoglobin with low oxygen affinity. For patients with hemoglobinopathies, it is well-established that hematopoietic stem cell transplantation provides a complete cure, but the literature on its role for those with Hb Hammersmith is limited. A seven-month-old girl who was examined for anemia and splenomegaly was followed up for congenital hemolytic anemia. The patient with visible cyanosis of the lips and whose p50 was low in blood gas was diagnosed with Hb Hammersmith through the DNA sequence analysis. During the follow-up, frequent blood transfusions had to be given due to anemia aggravated by infections. Following a successful hematopoietic stem cell transplant from an HLA-matched sibling, the patient completely recovered from Hb Hammersmith. The case is presented because of its rarity.en_US
dc.identifier.doi10.1080/03630269.2023.2219007
dc.identifier.issn0363-0269
dc.identifier.issn1532-432X
dc.identifier.pmid37605549en_US
dc.identifier.scopus2-s2.0-85168457039en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1080/03630269.2023.2219007
dc.identifier.urihttps://hdl.handle.net/11454/100549
dc.identifier.wosWOS:001051735900001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofHemoglobinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectHemoglobin Hammersmithen_US
dc.subjecthematopoietic stem cell transplantationen_US
dc.subjectlow oxygen affinity hemoglobin varianten_US
dc.subjectp50en_US
dc.subject>en_US
dc.subjectSevere Hemolytic-Anemiaen_US
dc.subjectPerformance Liquid-Chromatographyen_US
dc.subjectUnstable Hb Hammersmithen_US
dc.subjectFunctional-Propertiesen_US
dc.subjectIdentificationen_US
dc.subjectDiagnosisen_US
dc.subjectMutationen_US
dc.titleSuccessful Treatment of a Child with Hemoglobin Hammersmith with Hematopoietic Stem Cell Transplantationen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu