Association of osteopontin and tumor necrosis factor-? levels with insulin resistance in obese patients with obstructive sleep apnea syndrome

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dc.contributor.authorSarac F.
dc.contributor.authorBasoglu O.K.
dc.contributor.authorGunduz C.
dc.contributor.authorBayrak H.
dc.contributor.authorBiray Avci C.
dc.contributor.authorAkcicek F.
dc.date.accessioned2019-10-27T08:33:42Z
dc.date.available2019-10-27T08:33:42Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: The aims of this study were to compare the tumor necrosis factor (TNF)-? and osteopontin levels, to identify the relationship between insulin resistance (IR) and osteopontin levels in obese patients with and without obstructive sleep apnea syndrome (OSAS). Method: The study population included 62 obese patients (35 males, 27 females) with OSAS and was compared with 26 obese patients (16 males, 10 females) without OSAS as a control group. Polysomnographic evaluation, spirometric tests and arterial blood gas sampling were performed on the obese patients with OSAS. Plasma levels of TNF-? and osteopontin were measured by enzyme-linked immunosorbent assays during the process. IR was estimated using the homeostasis model assessment (HOMA). Results: Mean plasma levels of fasting glucose, insulin, HOMA, liver function test, hematocrit, leukocyte, TSH, free T 4, fibrinogen, TNF-?, and osteopontin were similar in the 2 groups. In patients with OSAS, mean osteopontin levels were positively correlated with mean fasting insulin levels (r=0.306, p=0.01), HOMA (r=0.299, p=0.01), apnea-hypopnea index (r=0.377, p=0.03) and Epworth Sleepiness Scale (r=0.299, p=0.01). However, mean TNF-? levels were negatively correlated with Epworth Sleepiness Scale (r=-0.298, p=0.01) in the patients with OSAS. Conclusions: It was observed that TNF-? and osteopontin levels showed no difference between obese patients with and without OSAS. However, osteopontin levels increased with fasting insulin, IR, OSAS severity, and daytime sleepiness. ©2011, Editrice Kurtis.en_US
dc.identifier.doi10.3275/7287en_US
dc.identifier.endpage533en_US
dc.identifier.issn0391-4097
dc.identifier.issue7en_US
dc.identifier.pmid20935448en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage528en_US
dc.identifier.urihttps://doi.org/10.3275/7287
dc.identifier.urihttps://hdl.handle.net/11454/26854
dc.identifier.volume34en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Endocrinological Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInsulin resistanceen_US
dc.subjectObesityen_US
dc.subjectObstructive sleep apnea syndromeen_US
dc.subjectOsteopontinen_US
dc.subjectTNF-?en_US
dc.titleAssociation of osteopontin and tumor necrosis factor-? levels with insulin resistance in obese patients with obstructive sleep apnea syndromeen_US
dc.typeArticleen_US

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