AN EXPERIMENTAL INFECTIVE ENDOCARDITIS MODEL IN RATS

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dc.authoridKış, Mehmet/0000-0003-0775-8992
dc.authorwosidKış, Mehmet/AAE-3815-2021
dc.contributor.authorKose, Sukran
dc.contributor.authorKis, Tuba Tatli
dc.contributor.authorYilmaz, Canberk
dc.contributor.authorKis, Mehmet
dc.contributor.authorBaris, Mustafa
dc.contributor.authorDiniz, Gulden
dc.contributor.authorYilmaz, Osman
dc.date.accessioned2023-01-12T20:15:15Z
dc.date.available2023-01-12T20:15:15Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractObjective: Infective endocarditis (IE) is defined as infection of the endocardial surface of the heart. Updates are needed in the diagnosis and treatment of IE, as well as in animal models of IE. Based on this need, a new model of infective endocarditis induced by S. aureus was described in our study. Methods: This study was performed on 7 Wistar albino male rats, each aged six months and weighing 250-300 g. Underwent the surgical implantation of a 20 G catheter, to gain access to right common carotid artery. Twenty-four hours after implantation, 0.5 ml 100.000 colony forming unit (cfu) of S. aureus was injected via the tail vein and 3 days later echocardiography was performed and rats subsequently sacrificed. IE was later diagnosed histopathologically. Results: Two of the rats were exitus one day after S. auerus was given. The mortality rate of the experiment was 28.5%. Histopathological examination revealed vegetations and bacterial colonization were detected in the endocardium in all rats that protruded from the endocardium to the cardiac cavity. Conclusion: Our study is the first study in the literature to identify the IE rat model using the 20 G catheter. Due to the practical application of the surgical procedure (use of 20 G catheter) in our study, we think that it will provide much convenience to the researchers in the experimental research on IE diagnosis and treatment.en_US
dc.identifier.doi10.30621/jbachs.915263
dc.identifier.endpage99en_US
dc.identifier.issn2458-8938
dc.identifier.issn2564-7288
dc.identifier.issue3en_US
dc.identifier.startpage93en_US
dc.identifier.trdizinid505551en_US
dc.identifier.urihttps://doi.org/10.30621/jbachs.915263
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/505551
dc.identifier.urihttps://hdl.handle.net/11454/78390
dc.identifier.volume5en_US
dc.identifier.wosWOS:000713673500012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherDokuz Eylul Univ Inst Health Sciencesen_US
dc.relation.ispartofJournal Of Basic And Clinical Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInfective endocarditisen_US
dc.subjectMSSAen_US
dc.subjectraten_US
dc.subjectmodelen_US
dc.subjectBacterial-Endocarditisen_US
dc.titleAN EXPERIMENTAL INFECTIVE ENDOCARDITIS MODEL IN RATSen_US
dc.typeArticleen_US

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