Granulomatous disease in common variable immunodeficiency

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dc.contributor.authorArdeniz, Oemuer
dc.contributor.authorCunningham-Rundles, Charlotte
dc.date.accessioned2019-10-27T20:48:22Z
dc.date.available2019-10-27T20:48:22Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractGranulomatous disease occurs in 8-22% of patients with common variable immunodeficiency (CVID). We examined the clinical and immunologic information of all 37 of 455 (8.1%) CVID subjects with this complication. The median age at diagnosis of CVID was 26 (2-59). 14 had granulomas 1-18 years before diagnosis of CVID. In 6 detection of granulomas coincided with this diagnosis; for 17, granulomas were documented later. 54% had lung granulomas, 43% in lymph nodes and 32% in liver. 54% of the group had had autoimmune diseases, mostly immune thrombocytopenia and hemolytic anemia. 24% had had a splenectomy. Nineteen (51.3%) required steroid treatment for granulomas; other immune suppressants were used in some. Over 25 years 28.5% died (median age 37.5), but not significantly more when compared to our CVID patients without granulomas (19.8%). Those with lung granulomas had similar mortality to those with granulomas in other tissues. (C) 2009 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipNational Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [AI 101093, AI-467320, AI-48693]; NIAIDUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Allergy & Infectious Diseases (NIAID) [03-22]en_US
dc.description.sponsorshipThis work was supported by grants from the National Institutes of Health, AI 101093, AI-467320, AI-48693 and NIAID Contract 03-22 to CCR.en_US
dc.identifier.doi10.1016/j.clim.2009.05.001en_US
dc.identifier.endpage207en_US
dc.identifier.issn1521-6616
dc.identifier.issn1521-7035
dc.identifier.issue2en_US
dc.identifier.pmid19716342en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage198en_US
dc.identifier.urihttps://doi.org/10.1016/j.clim.2009.05.001
dc.identifier.urihttps://hdl.handle.net/11454/42700
dc.identifier.volume133en_US
dc.identifier.wosWOS:000271167800006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofClinical Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCommon variable immune deficiencyen_US
dc.subjectGranulomatous diseaseen_US
dc.subjectMortalityen_US
dc.subjectTNF-alphaen_US
dc.subjectLung diseaseen_US
dc.subjectAutoimmunityen_US
dc.titleGranulomatous disease in common variable immunodeficiencyen_US
dc.typeArticleen_US

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