Antibiotic use and Influencing Factors Among Hospitalized Patients with COVID-19: A Multicenter Point-Prevalence Study from Turkey

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dc.authoridKarabay, Oguz/0000-0003-1514-1685
dc.authoriddemirbaş, zehra/0000-0002-5814-5398
dc.authoridEREN KUTSOYLU, oya/0000-0003-3814-0474
dc.authoridSayar, Merve Sefa/0000-0002-0436-4122
dc.authoridKuzi, Semanur/0000-0001-6496-1773
dc.authoridUnver Ulusoy, Tulay/0000-0002-0172-2326
dc.authoridCag, Yasemin/0000-0002-9983-0308
dc.authorscopusid57200000454
dc.authorscopusid35764273000
dc.authorscopusid23060531400
dc.authorscopusid25225546400
dc.authorscopusid23008184300
dc.authorscopusid36158552200
dc.authorscopusid57219203549
dc.authorwosidKarabay, Oguz/HHN-5893-2022
dc.authorwosidCag, Yasemin/S-7343-2016
dc.authorwosidBektaş, Begüm/GQB-4719-2022
dc.authorwosiddemirbaş, zehra/GPK-7612-2022
dc.authorwosidEREN KUTSOYLU, oya/Y-9180-2018
dc.authorwosidSayar, Merve Sefa/GVS-7640-2022
dc.authorwosidkul, gülnur/GQY-4432-2022
dc.contributor.authorSencan, Irfan
dc.contributor.authorCag, Yasemin
dc.contributor.authorKarabay, Oguz
dc.contributor.authorKurtaran, Behice
dc.contributor.authorGuclu, Ertugrul
dc.contributor.authorOgutlu, Aziz
dc.contributor.authorDemirbas, Zehra
dc.date.accessioned2023-01-12T20:16:30Z
dc.date.available2023-01-12T20:16:30Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractBackground: Broad-spectrum empirical antimicrobials arc frequently prescribed for patients with coronavirus disease 2019 (COVID-19) despite the lack of evidence for bacterial coinfection. Aims: We aimed to cross-sectionally determine the frequency of antibiotics use, type of antibiotics prescribed, and the factors influencing antibiotics use in hospitalized patients with COVID-19 confirmed by polymerase chain reaction. Study Design: The study was a national, multicenter, retrospective. and single-day point prevalence study. Methods: This was a national, multicenter, retrospective, and single-day point-prevalence study, conducted in the 24-h period between 00:00 and 24:00 on November 18, 2020, during the start of the second COVID-19 peak in Turkey. Results: A total of 1500 patients hospitalized with a diagnosis of COVID-19 were included in the study. The mean age +/- standard deviation of the patients was 65.0 +/- 15.5, and 56.2% (n = 843) of these patients were men. Of these hospitalized patients, 11.9% (n = 178) were undergoing invasive mechanical ventilation or ECMO. It was observed that 1118 (74.5%) patients were receiving antibiotics, of which 416 (372%) were prescribed a combination of antibiotics. In total, 71.2% of the patients had neither a clinical diagnosis nor microbiological evidence for prescribing antibiotics. In the multivariate logistic regression analysis, hospitalization in a state hospital (p < 0.001), requiring any supplemental oxygen (p = 0.005). presence of moderate/diffuse lung involvement (p < 0.001), C-reactive protein >10 ULT coefficient (p < 0.001), lymphocyte count < 800 (p = 0.007), and clinical diagnosis and/or confirmation by culture (p <0.001) were found to be independent factors associated with increased antibiotic use. Conclusion: The necessity of empirical antibiotics use in patients with COVID-19 should be reconsidered according to their clinical, imaging, and laboratory findings.en_US
dc.identifier.doi10.4274/balkanmedj.galenos.2022.2021-11-62
dc.identifier.endpage217en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue3en_US
dc.identifier.pmid35611705en_US
dc.identifier.scopus2-s2.0-85133362344en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage209en_US
dc.identifier.urihttps://doi.org/10.4274/balkanmedj.galenos.2022.2021-11-62
dc.identifier.urihttps://hdl.handle.net/11454/78725
dc.identifier.volume39en_US
dc.identifier.wosWOS:000806079300007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBacterial Coinfectionen_US
dc.subjectStewardshipen_US
dc.titleAntibiotic use and Influencing Factors Among Hospitalized Patients with COVID-19: A Multicenter Point-Prevalence Study from Turkeyen_US
dc.typeArticleen_US

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