Exanthematous drug eruption due to valsartan

Basit Öğe Kaydı
dc.contributor.authorOzturk, Gunseli
dc.contributor.authorTurk, Bengu Gerceker
dc.contributor.authorSenturk, Bircan
dc.contributor.authorTurkmen, Meltem
dc.contributor.authorKandiloglu, Gulsen
dc.date.accessioned2019-10-27T21:40:45Z
dc.date.available2019-10-27T21:40:45Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: Valsartan is an angiotensin II receptor blocker (ARB) used for treatment of hypertension. The well-known adverse effects of valsartan are dizziness, headache and cough. Valsartan-related cutaneous side effects have been reported previously in a limited number of case reports. Materials and methods: A 47-year-old man admitted with diffuse, itchy erythematous maculopapular eruption all over the body. He has been taking 160 mg valsartan daily for 10 days before onset of the eruption. On the third day of valsartan therapy, erythema had appeared over the face and spread throughout the whole body within a week. Histopathologic examination of the lesions showed lymphocyte exocytosis, spongiosis, necrotic keratinocytes in the epidermis, and mixed inflammatory cell infiltrates including perivascular eosinophils in the dermis. The patient was diagnosed as drug reaction due to valsartan with historical, clinical and histopathologic features. Discussion and conclusion: Most common antihypertensive agents including diuretics, beta blockers, calcium-channel blockers, angiotensin-converting enzyme inhibitors have many cutaneous side effects. However, there are a few reports about the cutaneous side effects of ARBs. Physicians should be aware of the cutaneous side effects of this commonly used agent and valsartan should be considered as a triggering factor of an exanthematous drug reactions.en_US
dc.identifier.doi10.3109/15569527.2011.647179en_US
dc.identifier.endpage337en_US
dc.identifier.issn1556-9527
dc.identifier.issue4en_US
dc.identifier.pmid22257082en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage335en_US
dc.identifier.urihttps://doi.org/10.3109/15569527.2011.647179
dc.identifier.urihttps://hdl.handle.net/11454/46339
dc.identifier.volume31en_US
dc.identifier.wosWOS:000310705800011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofCutaneous and Ocular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectValsartanen_US
dc.subjectdrug reactionen_US
dc.subjectskinen_US
dc.subjecttoxicologyen_US
dc.titleExanthematous drug eruption due to valsartanen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu