Lipid profile, familial hypercholesterolemia prevalence, and 2-year cardiovascular outcome assessment in acute coronary syndrome: Real-life data of a retrospective cohort [Akut koroner sendrom olgularında iki yıllık kardiyovasküler sonlanım değerlendirmesi, lipit profili ve ailevi hiperkolesterolemi sıklığı: Bir geriye dönük kohorta ait gerçek yaşam verileri]

Basit Öğe Kaydı
dc.contributor.authorKayıkçıoğlu M.
dc.contributor.authorAlan B.
dc.contributor.authorPayzın S.
dc.contributor.authorCan L.H.
dc.date.accessioned2019-10-27T08:01:20Z
dc.date.available2019-10-27T08:01:20Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: The aim of this retrospective study based on real-life data was to evaluate the lipid profile and demographic, clinical, and laboratory features of patients with acute coronary syndrome (ACS) at a tertiary center and to examine the mortality rate. Methods: Information including endpoint data for at least 2 years following the index ACS event was retrieved from hospital records. Patients without sufficient follow-up data were called by phone. Modified Dutch Lipid Clinic Network criteria were used to identify the presence of familial hypercholesterolemia (FH). Factors affecting mortality in the 2-year followup period were evaluated using Cox regression analysis. Results: A total of 985 ACS patients (215 females) between 21 and 93 years of age were included. The females were older and had a lower smoking rate than the males. In females, the history of obesity and hypertension, the diabetes rate, and the thyroid-stimulating hormone level were higher than those of the males. In 95.6% of the patients, lipid parameters were measured upon hospital admission. No significant difference in dyslipidemia frequency was observed between genders. The frequency of FH was 7.6%. The rate of lipid-lowering drug use was <20% at admission, >90% at discharge, and decreased to 50% in the follow-up period. The mortality rate was 3.8% in the in-hospital period and 8.1% during the 2 years of follow-up. Conclusion: The mortality rate in ACS patients was 3.8% in the in-hospital period and 8.1% in the 2-year follow-up period. The frequency of hypercholesterolemia was 89.5% and the rate of lipid-lowering drug use was insufficient. Secondary prevention after ACS was not adequately employed even at a tertiary center. The FH frequency was 7.6% and those with FH were observed to have ACS at a younger age than those without. © 2019 Türk Kardiyoloji Derneği,en_US
dc.identifier.doi10.5543/tkda.2019.07360en_US
dc.identifier.endpage486en_US
dc.identifier.issn1016-5169
dc.identifier.issue6en_US
dc.identifier.pmid31483296en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage476en_US
dc.identifier.urihttps://doi.org/10.5543/tkda.2019.07360
dc.identifier.urihttps://hdl.handle.net/11454/24967
dc.identifier.volume47en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherTurkish Society of Cardiologyen_US
dc.relation.ispartofTurk Kardiyoloji Dernegi Arsivien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute coronary syndromeen_US
dc.subjectFamilial hypercholesterolemiaen_US
dc.subjectLow-density lipoprotein cholesterolen_US
dc.subjectMortalityen_US
dc.subjectSecondary preventionen_US
dc.titleLipid profile, familial hypercholesterolemia prevalence, and 2-year cardiovascular outcome assessment in acute coronary syndrome: Real-life data of a retrospective cohort [Akut koroner sendrom olgularında iki yıllık kardiyovasküler sonlanım değerlendirmesi, lipit profili ve ailevi hiperkolesterolemi sıklığı: Bir geriye dönük kohorta ait gerçek yaşam verileri]en_US
dc.typeArticleen_US

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