A Neuropsychiatric and Neuroimaging Study of Unilateral and Bilateral Striatal Ischemic Lesions

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dc.authorscopusid7003717249
dc.authorscopusid57223616502
dc.authorscopusid57201367527
dc.contributor.authorKumral, E.
dc.contributor.authorÇetin, F.E.
dc.contributor.authorÖzdemir, H.N.
dc.date.accessioned2024-08-25T18:46:18Z
dc.date.available2024-08-25T18:46:18Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractOBJECTIVE: Neuropsychiatric disorders after striatal territory stroke have not been studied systematically. The investigators aimed to study the spectrum of cognitive and behavioral disorders following striatal infarcts. METHODS: Different aspects of cognitive functions, including executive, frontal lobe, memory, visuospatial, language, and semantic processing, were assessed among patients with striatal infarct. Structural MRI data sets were obtained 3 months after stroke to delineate affected territories of the striatum. MRIcroGL software was used to acquire multiple layers of images, generate volume renderings, and draw volumes of interest. To determine the brain locus most frequently affected in patients with distinct cognitive disorders, ischemic area distributions in patients with cognitive dysfunction versus those without cognitive impairment were contrasted. RESULTS: Among 60 patients in this study, six different striatal infarction types were significantly associated with seven different cognitive categories (p<0.001). Unilateral caudate lesion was characterized by attention, planning, and executive disorders (38%), and unilateral lentiform infarct was characterized by executive (36%) and frontal (36%) dysfunctions. Bilateral caudate infarcts caused impairments in frontal and executive functions (75%), as well as in autobiographical (50%) and episodic (50%) memory. In those with bilateral caudate plus lentiform infarcts, all components of frontal and executive functions were dramatically impaired. The anteromedial striatum was affected more frequently in patients with language impairment compared with patients with other types of cognitive dysfunction (p<0.001). CONCLUSIONS: Following striatal stroke, a wide range of frontal-like cognitive impairments occurred, along with impaired working memory, declarative memory, executive function, speech fluency, and motor function.en_US
dc.identifier.doi10.1176/appi.neuropsych.21030083
dc.identifier.endpage58en_US
dc.identifier.issn1545-7222
dc.identifier.issue1en_US
dc.identifier.pmid35872616en_US
dc.identifier.scopus2-s2.0-85146363881en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage48en_US
dc.identifier.urihttps://doi.org/10.1176/appi.neuropsych.21030083
dc.identifier.urihttps://hdl.handle.net/11454/101864
dc.identifier.volume35en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNLM (Medline)en_US
dc.relation.ispartofThe Journal of neuropsychiatry and clinical neurosciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectBasal Gangliaen_US
dc.subjectCerebral Ischemiaen_US
dc.subjectCognitive Disordersen_US
dc.subjectExecutive Disorderen_US
dc.subjectStriatumen_US
dc.subjectStrokeen_US
dc.subjectcerebrovascular accidenten_US
dc.subjectcomplicationen_US
dc.subjectcorpus striatumen_US
dc.subjectdiagnostic imagingen_US
dc.subjectexecutive functionen_US
dc.subjecthumanen_US
dc.subjectinfarctionen_US
dc.subjectmemory disorderen_US
dc.subjectneuroimagingen_US
dc.subjectneuropsychological testen_US
dc.subjectpathologyen_US
dc.subjectCorpus Striatumen_US
dc.subjectExecutive Functionen_US
dc.subjectHumansen_US
dc.subjectInfarctionen_US
dc.subjectMemory Disordersen_US
dc.subjectNeuroimagingen_US
dc.subjectNeuropsychological Testsen_US
dc.subjectStrokeen_US
dc.titleA Neuropsychiatric and Neuroimaging Study of Unilateral and Bilateral Striatal Ischemic Lesionsen_US
dc.typeArticleen_US

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