Light, electron microscopic and immunohistochemical study of the effect of low-dose aspirin during the proestrus phase on rat endometrium in the preimplantation period

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dc.contributor.authorAtes, Utku
dc.contributor.authorBaka, Meral
dc.contributor.authorTurgut, Mehmet
dc.contributor.authorUyanikgil, Yigit
dc.contributor.authorUlker, Sibel
dc.contributor.authorYilmaz, Ozlem
dc.contributor.authorTavmergen, Erol
dc.contributor.authorYurtseven, Mine
dc.date.accessioned2019-10-27T19:35:05Z
dc.date.available2019-10-27T19:35:05Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractOBJECTIVE: To evaluate structural alterations in rat endometrium at preimplantation following treatment with aspirin beginning from proestrus by light microscopy, electron microscopy and immunohistochemical techniques. STUDY DESIGN: Twenty rats were divided into control (n =10) and experimental (n =10) groups. Experimental rats were treated with low-dose aspirin daily (2 mg/kg/day) during estrus, beginning from the proestrus phase, mated at end of cycle and treated with aspirin. Untreated pregnant rats were the control group. Rats in both groups were sacrificed at the 84th pregnancy hour; the uterus was rapidly removed and dissected free of surrounding adipose tissue. Uteri specimensfrom nonpregnant rats were transferred into fixative solution and processed for light, electron microscopic and immunohistochemical study. RESULTS: Light and electron microscopy of endometrium from control rats conformed to mid-diestrus phase; endometrial histology of the aspirin-treated group conformed to late diestrus phase. The endometrial layer was significantly thicker in the aspirin-treated group compared to the untreated control group (p < 0.001). No significant difference was found in vessel number between groups. Staining with alpha V integrin was more dense in the aspirin-treated group. CONCLUSION: Based on histologic findings, we suggest low-dose aspirin has positive effects on preparing endometrium before implantation.en_US
dc.identifier.endpage102en_US
dc.identifier.issn0884-6812
dc.identifier.issue2en_US
dc.identifier.pmid17484273en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage95en_US
dc.identifier.urihttps://hdl.handle.net/11454/39690
dc.identifier.volume29en_US
dc.identifier.wosWOS:000245687200005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytology and Histologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectaspirinen_US
dc.subjectendometriumen_US
dc.subjectpreimplantationen_US
dc.subjectraten_US
dc.titleLight, electron microscopic and immunohistochemical study of the effect of low-dose aspirin during the proestrus phase on rat endometrium in the preimplantation perioden_US
dc.typeArticleen_US

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