Daptomycin versus Vancomycin in Treatment of Methicillin-Resistant Staphylococcus aureus Meningitis in an Experimental Rabbit Model

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dc.contributor.authorBardak-Ozcem, Selin
dc.contributor.authorTurhan, Tuncer
dc.contributor.authorSipahi, Oguz Resat
dc.contributor.authorArda, Bilgin
dc.contributor.authorPullukcu, Husnu
dc.contributor.authorYamazhan, Tansu
dc.contributor.authorIsikgoz-Tasbakan, Meltem
dc.contributor.authorSipahi, Hilal
dc.contributor.authorUlusoy, Sercan
dc.date.accessioned2019-10-27T21:41:37Z
dc.date.available2019-10-27T21:41:37Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractIn this study, we aimed to compare the antibacterial activities of daptomycin and vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) meningitis (induced by MRSA strain ATCC 43300) in an experimental rabbit meningitis model. After an 8-h period of treatment, bacterial counts decreased significantly in both treatment groups compared to the control group (P<0.05). However, there was no statistically significant difference between treatment groups. Our results suggest that the antibacterial activity of daptomycin is similar to vancomycin for treatment in the experimental MRSA meningitis model in rabbits.en_US
dc.description.sponsorshipEge UniversityEge Universityen_US
dc.description.sponsorshipThis study was supported by a grant from Ege University. S.U. and O.R.S. have both received a speaker's honorarium from Novartis.en_US
dc.identifier.doi10.1128/AAC.01996-12en_US
dc.identifier.endpage1558en_US
dc.identifier.issn0066-4804
dc.identifier.issue3en_US
dc.identifier.pmid23318792en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1556en_US
dc.identifier.urihttps://doi.org/10.1128/AAC.01996-12
dc.identifier.urihttps://hdl.handle.net/11454/46707
dc.identifier.volume57en_US
dc.identifier.wosWOS:000314968100066en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Soc Microbiologyen_US
dc.relation.ispartofAntimicrobial Agents and Chemotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleDaptomycin versus Vancomycin in Treatment of Methicillin-Resistant Staphylococcus aureus Meningitis in an Experimental Rabbit Modelen_US
dc.typeArticleen_US

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