Synthesis, crystal structures, in vitro DNA binding, antibacterial and cytotoxic activities of new di- and polynuclear silver(I) saccharinate complexes with tertiary monophosphanes

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dc.contributor.authorYilmaz, Veysel T.
dc.contributor.authorGocmen, Elif
dc.contributor.authorIcsel, Ceyda
dc.contributor.authorCengiz, Murat
dc.contributor.authorSusluer, Sunde Y.
dc.contributor.authorBuyukgungor, Orhan
dc.date.accessioned2019-10-27T22:05:20Z
dc.date.available2019-10-27T22:05:20Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractFour new silver(I) saccharinate (sac) complexes, [Ag(mu-sac)(PPh3)](2) (1), [Ag(mu-sac)(PPh2CY)](2) (2), [Ag(mu-sac)(PPhCy2)](2) (3) and [Ag(mu-sac)(PCy3)](n) (4), where PPh3 = triphenylphosphane, PPh2Cy = cyclohexyldiphenylphosphane, PPhCy2 = dicyclohexylphenylphosphane and PCy3 = tricyclohexylphosphane, have been synthesized and fully characterized by elemental analysis, IR, NMR, ESI-MS and single crystal X-ray diffraction. Fluorescence ethidium bromide displacement indicate that all complexes bind to fish sperm (FS) DNA by intercalation with binding constants (K-A) of 29.1 +/- 0.26 x 10(5) M-1 for 1, 2.54 +/- 0.12 x 10(5) M-1 for 2, 2.42 +/- 0.08 x 10(5) M-1 for 3, 0.19 +/- 0.03 x 10(5) M-1 for 4. The relative viscosities of the FS-DNA solutions increase with increasing of the complex concentration, providing strong evidence for the intercalation mode. The gel electrophoresis assay further confirms their binding with the pBR322 plasmid DNA. The MIC values of the silver(I) complexes are generally higher than those of AgNO3 and silver sulfadiazine, but 1 presents a promising activity against Salmonella typhimurium and Staphylococcus aureus. All complexes are highly cytotoxic on human lung carcinoma (A549) and human breast adenocarcinoma (MCF-7) cell lines with IC50 values ranging from 0.82 to 3.13 mu M. (C) 2013 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipUludag UniversityUludag University [UAP(F)-2011/36]en_US
dc.description.sponsorshipWe are grateful to Uludag University for the financial support given to the project (Project No: UAP(F)-2011/36).en_US
dc.identifier.doi10.1016/j.jphotobiol.2013.12.014en_US
dc.identifier.endpage42en_US
dc.identifier.issn1011-1344
dc.identifier.pmid24480545en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage31en_US
dc.identifier.urihttps://doi.org/10.1016/j.jphotobiol.2013.12.014
dc.identifier.urihttps://hdl.handle.net/11454/48356
dc.identifier.volume131en_US
dc.identifier.wosWOS:000333790100004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofJournal of Photochemistry and Photobiology B-Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSilver(I)en_US
dc.subjectSaccharinateen_US
dc.subjectPhosphineen_US
dc.subjectDNA bindingen_US
dc.subjectAntibacterial activityen_US
dc.subjectCytotoxic activityen_US
dc.titleSynthesis, crystal structures, in vitro DNA binding, antibacterial and cytotoxic activities of new di- and polynuclear silver(I) saccharinate complexes with tertiary monophosphanesen_US
dc.typeArticleen_US

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