Effects of 2,4-dichlorophenoxyacetic acid formulation on medulla spinalis of Poecilia reticulata: A histopathological study

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dc.contributor.authorUyanikgil, Yigit
dc.contributor.authorYalcinkaya, Murat
dc.contributor.authorAtes, Utku
dc.contributor.authorBaka, Meral
dc.contributor.authorKarakisi, Hatice
dc.date.accessioned2019-10-27T20:46:09Z
dc.date.available2019-10-27T20:46:09Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractThis study investigated the possible effects of a commonly used foliar herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) formulation on medulla spinalis of lebistes. Fish were exposed to 2,4-D (15, 30, 45 ring L-1), behavioral changes were monitored. Fish were fixed, histopathological examination was carried out on sections taken from the upper parts of the fish body. Histopathology showed increase in neuronal loss, swelling indicating formation of intracellular edema, vacuolization noticed as the formation of vacuoles within or adjacent to cells, deformation in the Nissl granules, pyknosis and gliosis in medulla spinalis. Behavioral changes were decreased general activity, grouping, shortness in breath. sudden rotations and jumping, loss of equilibrium and colour. In conclusion, this commercial formulation of 2,4-D is considerably neurotoxic to lebistes. Fish constitute the last link in the chain of the feeding cycle in aquatic eco-system, number of studies investigating acute and chronic neurotoxicity of various herbicides in fish should be increased. (C) 2009 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.chemosphere.2009.06.018en_US
dc.identifier.endpage1391en_US
dc.identifier.issn0045-6535
dc.identifier.issn1879-1298
dc.identifier.issue10en_US
dc.identifier.pmid19577790en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1386en_US
dc.identifier.urihttps://doi.org/10.1016/j.chemosphere.2009.06.018
dc.identifier.urihttps://hdl.handle.net/11454/42357
dc.identifier.volume76en_US
dc.identifier.wosWOS:000270123100011en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofChemosphereen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject2,4-Dichlorophenoxyacetic acid (2,4-D)en_US
dc.subjectMedulla spinalisen_US
dc.subjectLebistesen_US
dc.subjectPoecilia reticulataen_US
dc.subjectNeurotoxicityen_US
dc.subjectBehavioral toxicityen_US
dc.titleEffects of 2,4-dichlorophenoxyacetic acid formulation on medulla spinalis of Poecilia reticulata: A histopathological studyen_US
dc.typeArticleen_US

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