Current updates on the European and WHO registered clinical trials of coronavirus disease 2019 (COVID-19)

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dc.contributor.authorVerma, Henu Kumar
dc.contributor.authorMerchant, Neha
dc.contributor.authorVerma, Manish Kumar
dc.contributor.authorKuru, Cansu Ilke
dc.contributor.authorSingh, Anand Narayan
dc.contributor.authorUlucan, Fulden
dc.contributor.authorBhaskar, L. V. K. S.
dc.date.accessioned2021-05-03T20:37:01Z
dc.date.available2021-05-03T20:37:01Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractCoronavirus disease 2019 (COVID-19) is a major public health concern currently. To date, there are no approved antiviral drugs or vaccines against this transmissible disease. This report sheds light on available information for a better understanding of clinical trials and pharmacotherapy related to COVID-19. MEDLINE, PubMed, EMBASE, Scopus databases, Web of Science, WHO, and EU clinical trial sites were used to perform comparative analysis. Information was collected on the use of therapeutic agents for human therapy in patients with COVID-19 up to May 2020. We have extracted data from 60 clinical trials. Amongst these trials, 34 were from the European Union database of clinical trials and 26 from the National Institute of Health. The data selection procedure includes active, completed, and recruitment in progress status. Most of the clinical trials are ongoing and hence, there is a lack of precise results for the treatment.There is a lack of high-quality clinical evidence. The protocol to be developed requires large randomized clinical trials with a combination of available drugs and prospective therapies. We propose the usage of a large number of cases and different statistical analyses to conduct systematic clinical trials. This could provide comprehensive information about the clinical trial and potential therapeutic progress.en_US
dc.identifier.doi10.1016/j.bj.2020.07.008en_US
dc.identifier.endpage433en_US
dc.identifier.issn2319-4170
dc.identifier.issn2320-2890
dc.identifier.issue5en_US
dc.identifier.pmid32792167en_US
dc.identifier.startpage424en_US
dc.identifier.urihttps://doi.org/10.1016/j.bj.2020.07.008
dc.identifier.urihttps://hdl.handle.net/11454/70312
dc.identifier.volume43en_US
dc.identifier.wosWOS:000592366800004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofBiomedical Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectCorona pandemicen_US
dc.subjectVaccinationen_US
dc.subjectClinical trialsen_US
dc.subjectTherapeuticen_US
dc.titleCurrent updates on the European and WHO registered clinical trials of coronavirus disease 2019 (COVID-19)en_US
dc.typeReview Articleen_US

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