Correlation of Prostate-Imaging Reporting and Data Scoring System scoring on multiparametric prostate magnetic resonance imaging with histopathological factors in radical prostatectomy material in Turkish prostate cancer patients: a multicenter study of the Urooncology Association

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dc.contributor.authorKizilay, Fuat
dc.contributor.authorCelik, Serdar
dc.contributor.authorSozen, Sinan
dc.contributor.authorOzveren, Bora
dc.contributor.authorEskicorapci, Saadettin
dc.contributor.authorOzgen, Mahir
dc.contributor.authorCal, Cag
dc.date.accessioned2021-05-03T20:38:20Z
dc.date.available2021-05-03T20:38:20Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Histopathological features after radical prostatectomy (RP) provide important information for the prognosis of prostate cancer (PCa). The possible correlations between Prostate-Imaging Reporting and Data Scoring System (PIRADS) scores in multiparametric magnetic resonance imaging (mpMRI) may also be predictive for prognosis. in this study, we aimed to evaluate the correlation of PIRADS scores with histopathological data. Methods: A total of 177 patients who underwent preoperative mpMRI and RP for PCa from eight institutions were included in the study. Correlation of PIRADS score in preoperative mpMRI with adverse histopathological factors in RP specimen was investigated using univariate and multivariate analyses. Results: The relationship between PIRADS score and postoperative extracapsular extension, lymphovascular invasion, and seminal vesicle involvement was significant (P < 0.001, P = 0.032, and P = 0.007, respectively). Although the PIRADS score was significantly correlated with the number of dissected lymph nodes (p = 0.026), it had no significant correlation with the number of positive nodes (P = 0.611). Total Gleason score, extracapsular extension, seminal vesicle invasion, and number of lymph nodes were found to be independent factors, which correlated with high PIRADS scores in ordinal logistic regression analysis. Conclusion: PIRADS scoring system in mpMRI showed a statistically significant correlation with adverse histopathological factors in RP specimen. A higher PIRADS score may help to predict a higher Gleason score, indicating clinically important PCa as well as poor prognotic factors such as extracapsular extension, lymphovascular invasion, and seminal vesicle invasion that may indicate a higher risk of recurrence and the need for additional treatment. (C) 2020 Asian Pacific Prostate Society. Publishing services by Elsevier B.V.en_US
dc.identifier.doi10.1016/j.prnil.2020.01.001en_US
dc.identifier.endpage15en_US
dc.identifier.issn2287-8882
dc.identifier.issn2287-903X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85080117048en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage10en_US
dc.identifier.urihttps://doi.org/10.1016/j.prnil.2020.01.001
dc.identifier.urihttps://hdl.handle.net/11454/70379
dc.identifier.volume8en_US
dc.identifier.wosWOS:000523365800002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Incen_US
dc.relation.ispartofProstate Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHistopathologyen_US
dc.subjectMultiparametric magnetic resonance imaging prostateen_US
dc.subjectPIRADSen_US
dc.subjectProstate neoplasmsen_US
dc.titleCorrelation of Prostate-Imaging Reporting and Data Scoring System scoring on multiparametric prostate magnetic resonance imaging with histopathological factors in radical prostatectomy material in Turkish prostate cancer patients: a multicenter study of the Urooncology Associationen_US
dc.typeArticleen_US

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