Supraclavicular Lymphadenopathy: Should It Be Perceived as the Virchow's Node of Head and Neck Tumors?

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dc.contributor.authorAcar, Turker
dc.contributor.authorSavas, Recep
dc.contributor.authorKocacelebi, Kenan
dc.contributor.authorGuneyli, Serkan
dc.date.accessioned2019-10-27T22:12:26Z
dc.date.available2019-10-27T22:12:26Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: In this study, we aimed to determine the correlation between supraclavicular lymph node involvement (SLNI) and metastatic potential, frequency, and metastases predilection sites in patients diagnosed with various head and neck tumors (HNT) and staged via positron emission tomography/computed tomography (PET/CT) imaging. We also investigated the impact of different variables on SLNI. Patients and Methods: 270 patients diagnosed with HNT were enrolled in the study (194 males and 96 females, mean age 54.9 +/- 14.7 years (range 18-89 years)). Results: Nasopharyngeal carcinoma demonstrated significant SLNI (p < 0.01); however, other subtypes of HNT did not. In all HNT studied, no apparent metastatic predilection tendency for the supraclavicular region was observed, as opposed to the well-described Virchow's node. Age, gender, tumor size, and systemic metastases were not identified as statistically significant variables contributing to SLNI. Multivariate regression analysis revealed an increased cervical (p < 0.01) and thoracic (p = 0.001) lymph node involvement in patients with SLNI. Conclusion: SLNI with the possibility of metastasis was more frequently observed in nasopharyngeal carcinoma, advancing the nodal status without significantly influencing the T and M stages. A careful evaluation of this very small region is of critical importance for proper nodal staging in nasopharyngeal cancer patients.en_US
dc.identifier.doi10.1159/000369429en_US
dc.identifier.endpage730en_US
dc.identifier.issn2296-5270
dc.identifier.issn2296-5262
dc.identifier.issue12en_US
dc.identifier.pmid25531718en_US
dc.identifier.startpage726en_US
dc.identifier.urihttps://doi.org/10.1159/000369429
dc.identifier.urihttps://hdl.handle.net/11454/49432
dc.identifier.volume37en_US
dc.identifier.wosWOS:000346623300003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofOncology Research and Treatmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHead and neck tumoren_US
dc.subjectSupraclavicular lymph nodeen_US
dc.subjectPET/CTen_US
dc.titleSupraclavicular Lymphadenopathy: Should It Be Perceived as the Virchow's Node of Head and Neck Tumors?en_US
dc.typeArticleen_US

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