Clinical and immunological analysis of 23 adult patients with common variable immunodeficiency

Basit Öğe Kaydı
dc.contributor.authorArdeniz O.
dc.contributor.authorBaşoglu O.K.
dc.contributor.authorGünşar F.
dc.contributor.authorÜnsel M.
dc.contributor.authorBayraktaroglu S.
dc.contributor.authorMete N.
dc.contributor.authorGülbahar O.
dc.contributor.authorSin A.
dc.date.accessioned2019-10-26T22:34:21Z
dc.date.available2019-10-26T22:34:21Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Common variable immunodeficiency (CVID) is characterized by hypogammaglobulinemia, defective antibody production, and recurrent upper and lower airway tract infections. Objectives: To reveal the clinical heterogeneity of this condition, analyze the high frequency of respiratory and gastrointestinal complications despite satisfactory trough immunoglobulin (Ig) G levels, and determine the main difficulties in management and treatment. Methods: We performed a retrospective analysis of 23 patients (13 male and 10 female) diagnosed with CVID between 2001 and 2008. Results: The median diagnostic delay for females and males was 15 years (range, 1-32 years) and 8 years (range, 1-31 years), respectively. Restrictive, obstructive, and combined pulmonary function defects were determined in 23%, 27%, and 14% of patients, respectively. The most frequent findings on the thoracic computed tomography scan were bronchiectasis, mediastinal lymphadenopathy, fibrosis, ground-glass patterns, mosaic oligemia, peribronchial cuffing, and parenchymal nodules. Giardiasis and duodenal lymphoid hyperplasia were detected in 52% and 42% of the patients, respectively, and Helicobacter pylori in 42%. Vitamin A levels were normal, although B-carotene and/or vitamin E levels were decreased in patients presenting malabsorption-related symptoms. Malignancy was documented in 3 patients and decreased bone mineral density in 9 patients (3 had osteoporosis and 3 had osteomalacia). Conclusion: CVID is a multisystemic disease that should be managed by a multidisciplinary team. Intravenous immunoglobulin therapy and antibiotics do not seem to have a suppressive effect on granulomatous or inflammatory manifestations. More comprehensive studies based not only on peripheral blood but also on immunohistological analysis are necessary to shed light on the pathogenesis of these life-threatening complications. © 2010 Esmon Publicidad.en_US
dc.identifier.endpage236en_US
dc.identifier.issn1018-9068
dc.identifier.issue3en_US
dc.identifier.pmid20635788en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage222en_US
dc.identifier.urihttps://hdl.handle.net/11454/19811
dc.identifier.volume20en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Investigational Allergology and Clinical Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdultsen_US
dc.subjectAntibiotic prophylaxisen_US
dc.subjectCviden_US
dc.subjectGastrointestinal manifestationsen_US
dc.subjectGranulomatous diseaseen_US
dc.subjectIVIG therapyen_US
dc.subjectRespiratory manifestationsen_US
dc.titleClinical and immunological analysis of 23 adult patients with common variable immunodeficiencyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu