The effect of emotional faces on reward-related probability learning in depressed patients

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dc.authoridEroglu Koc, Seda/0000-0001-6474-3311
dc.authoridKizilates-Evin, Gozde/0000-0001-5518-6015
dc.contributor.authorKeskin-Gokcelli, Duygu
dc.contributor.authorKizilates-Evin, Gozde
dc.contributor.authorEroglu-Koc, Seda
dc.contributor.authorOguz, Kaya
dc.contributor.authorEraslan, Cenk
dc.contributor.authorKitis, Omer
dc.contributor.authorGonul, Ali Saffet
dc.date.accessioned2024-08-31T07:50:11Z
dc.date.available2024-08-31T07:50:11Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Existing research indicates that individuals with Major Depressive Disorder (MDD) exhibit a bias toward salient negative stimuli. However, the impact of such biased stimuli on concurrent cognitive and affective processes in individuals with depression remains inadequately understood. This study aimed to investigate the effects of salient environmental stimuli, specifically emotional faces, on reward-associated processes in MDD. Methods: Thirty-three patients with recurrent MDD and thirty-two healthy controls (HC) matched for age, sex, and education were included in the study. We used a reward-related associative learning (RRAL) task primed with emotional (happy, sad, neutral) faces to investigate the effect of salient stimuli on reward-related learning and decision-making in functional magnetic resonance imaging (fMRI). Participants were instructed to ignore emotional faces during the task. The fMRI data were analyzed using a full-factorial general linear model (GLM) in Statistical Parametric Mapping (SPM12). Results: In depressed patients, cues primed with sad faces were associated with reduced amygdala activation. However, both HC and MDD group exhibited reduced ventral striatal activity while learning reward-related cues and receiving rewards. Limitations: The patients'medication usage was not standardized. Conclusions: This study underscores the functional alteration of the amygdala in response to cognitive tasks presented with negative emotionally salient stimuli in the environment of MDD patients. The observed alterations in amygdala activity suggest potential interconnected effects with other regions of the prefrontal cortex. Understanding the intricate neural connections and their disruptions in depression is crucial for unraveling the complex pathophysiology of the disorder.en_US
dc.description.sponsorshipOffice of Scientific Research Projects, Ege University, Turkey [17 -TIP -039]en_US
dc.description.sponsorshipThis work was supported by grants from Office of Scientific Research Projects, Ege University, Turkey, Project number: 17 -TIP -039. The funding source had no role in the design and management of the study; collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.en_US
dc.identifier.doi10.1016/j.jad.2024.01.247
dc.identifier.endpage193en_US
dc.identifier.issn0165-0327
dc.identifier.issn1573-2517
dc.identifier.pmid38286231en_US
dc.identifier.scopus2-s2.0-85184080628en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage184en_US
dc.identifier.urihttps://doi.org/10.1016/j.jad.2024.01.247
dc.identifier.urihttps://hdl.handle.net/11454/105130
dc.identifier.volume351en_US
dc.identifier.wosWOS:001174358600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Affective Disordersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectProbabilistic Reward Learningen_US
dc.subjectReward Processingen_US
dc.subjectDepressionen_US
dc.subjectAmygdalaen_US
dc.subjectStriatumen_US
dc.subjectFmrien_US
dc.titleThe effect of emotional faces on reward-related probability learning in depressed patientsen_US
dc.typeArticleen_US

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