Characteristics of pediatric multiple sclerosis: The Turkish pediatric multiple sclerosis database

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dc.contributor.authorYılmaz Ü.
dc.contributor.authorAnlar B.
dc.contributor.authorGücüyener K.
dc.contributor.authorYaramış A.
dc.contributor.authorCansu A.
dc.contributor.authorÜnalp A.
dc.contributor.authorAksoy A.
dc.contributor.authorBayram A.K.
dc.contributor.authorKartal A.
dc.contributor.authorTosun A.
dc.contributor.authorSerdaroğlu A.
dc.contributor.authorKonuşkan B.
dc.contributor.authorSarıoğlu B.
dc.contributor.authorYüzbaşı B.K.
dc.contributor.authorKılıç B.
dc.contributor.authorTaşkın B.D.
dc.contributor.authorBulut C.
dc.contributor.authorYılmaz C.
dc.contributor.authorYarar C.
dc.contributor.authorOkuyaz Ç.
dc.contributor.authorGençsel Ç.
dc.contributor.authorYüksel D.
dc.contributor.authorArslan E.A.
dc.contributor.authorGürkaş E.
dc.contributor.authorFaruk incecik
dc.contributor.authorSerdaroğlu G.
dc.contributor.authorDeda G.
dc.contributor.authorGürbüz G.
dc.contributor.authorGümüş H.
dc.contributor.authorAcer H.
dc.contributor.authorTekgül H.
dc.contributor.authorÇaksen H.
dc.contributor.authorPer H.
dc.contributor.authorErol İ.
dc.contributor.authorÇarman K.B.
dc.contributor.authorCanpolat M.
dc.contributor.authorÖzkan M.
dc.contributor.authorDirek M.Ç.
dc.contributor.authorKutluk M.G.
dc.contributor.authorArslan M.
dc.contributor.authorSönmez F.M.
dc.contributor.authorDündar N.O.
dc.contributor.authorKoçak O.
dc.contributor.authorAydın Ö.F.
dc.contributor.authorToptaş Ö.
dc.contributor.authorDuman Ö.
dc.contributor.authorHergüner Ö.
dc.contributor.authorBozkurt Ö.
dc.contributor.authorArıcan P.
dc.contributor.authorYılmaz S.
dc.contributor.authorGökben S.
dc.contributor.authorIşıkay S.
dc.contributor.authorKumandaş S.
dc.contributor.authorEdizer S.
dc.contributor.authorKurul S.H.
dc.contributor.authorSaygı S.
dc.contributor.authorTeber S.
dc.contributor.authorGüngör S.
dc.contributor.authorAltunbaşak Ş.
dc.contributor.authorHaspolat Ş.
dc.contributor.authorSezer T.
dc.contributor.authorYılmaz T.S.
dc.contributor.authorYiş U.
dc.contributor.authorÖztoprak Ü.
dc.contributor.authorAydoğmuş Ü.
dc.contributor.authorTopçu Y.
dc.contributor.authorÖztürk Z.
dc.contributor.authorKaralök Z.S.
dc.date.accessioned2019-10-26T21:16:06Z
dc.date.available2019-10-26T21:16:06Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective To document the clinical and paraclinical features of pediatric multiple sclerosis (MS) in Turkey. Methods Data of MS patients with onset before age 18 years (n = 193) were collected from 27 pediatric neurology centers throughout Turkey. Earlier-onset (<12 years) and later-onset (?12 years) groups were compared. Results There were 123 (63.7%) girls and 70 (36.3%) boys aged 4–17 years, median 14 years at disease onset. Family history of MS was 6.5%. The first presentation was polysymptomatic in 55.4% of patients, with brainstem syndromes (50.3%), sensory disturbances (44%), motor symptoms (33.2%), and optic neuritis (26.4%) as common initial manifestations. Nineteen children had facial paralysis and 10 had epileptic seizures at first attack; 21 (11%) were initially diagnosed with acute disseminated encephalomyelitis (ADEM). Oligoclonal bands were identified in 68% of patients. Magnetic resonance imaging revealed periventricular (96%), cortical/juxtacortical (64.2%), brainstem (63%), cerebellum (51.4%), and spinal cord (67%) involvement. Visual evoked potentials (VEP) were abnormal in 52%; serum 25-hydroxyvitamin D levels were low in 68.5% of patients. The earlier-onset group had a higher rate of infection/vaccination preceding initial attack, initial diagnosis of ADEM, longer interval between first 2 attacks, and more disability accumulating in the first 3 years of the disease. Conclusion Brainstem and cerebellum are common sites of clinical and radiological involvement in pediatric-onset MS. VEP abnormalities are frequent even in patients without history of optic neuropathy. Vitamin D status does not appear to affect the course in early disease. MS beginning before 12 years of age has certain characteristics in history and course. © 2017 European Paediatric Neurology Societyen_US
dc.identifier.doi10.1016/j.ejpn.2017.06.004en_US
dc.identifier.endpage872en_US
dc.identifier.issn1090-3798
dc.identifier.issue6en_US
dc.identifier.pmid28694135en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage864en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejpn.2017.06.004
dc.identifier.urihttps://hdl.handle.net/11454/16149
dc.identifier.volume21en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW.B. Saunders Ltden_US
dc.relation.ispartofEuropean Journal of Paediatric Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectImagingen_US
dc.subjectMagnetic resonanceen_US
dc.subjectMultiple sclerosisen_US
dc.subjectPediatricen_US
dc.subjectRelapseen_US
dc.subjectVisual evoked potentialsen_US
dc.subjectVitamin Den_US
dc.titleCharacteristics of pediatric multiple sclerosis: The Turkish pediatric multiple sclerosis databaseen_US
dc.typeArticleen_US

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