Evaluation of the serum levels of Mannose binding lectin-2, tenascin-C, and total antioxidant capacity in patients with coronary artery disease

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dc.authorscopusid57247921500
dc.authorscopusid16834614700
dc.authorscopusid55565668500
dc.authorscopusid57216431373
dc.authorscopusid57190403532
dc.contributor.authorMehri, Hamed
dc.contributor.authorAslanabadi, Naser
dc.contributor.authorNourazarian, Alireza
dc.contributor.authorShademan, Behrouz
dc.contributor.authorKhaki-Khatibi, Fatemeh
dc.date.accessioned2023-01-12T19:49:48Z
dc.date.available2023-01-12T19:49:48Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractBackground Coronary artery disease (CAD) develops as a result of atherosclerosis. Atherosclerosis is a condition that leads to clogged arteries and can be caused by a variety of factors. Several studies have shown that various factors contribute to the development and progression of CAD. The aim of this study was to investigate the serum levels of MBL-2, TNC and TAC in patients with CAD and the relationship between these biochemical parameters and the progression of CAD. Methods In this study, 60 serum samples were obtained from CAD patients as the case group and 20 healthy serum samples as the control group. Serum levels of MBL-2 and TNC were measured by the ELISA method. Serum TAC level was determined by calorimetry (spectrophotometry). In addition, MDA serum level was measured by reaction with thiobarbituric acid (TBA). Results The mean age in the case and control groups was 58.4 +/- 9.5 years and 85 +/- 9.8 years, respectively. There was no significant difference in age, sex and family history in patients with CAD (p > 0.05), but there was a significant difference in blood pressure and smoking history (p > 0.05). Serum cholesterol, triglyceride, and LDL levels were significantly increased in the case group compared to the control group, while serum HDL-C levels were significantly decreased in the case group. Serum levels of MBL-2, TNC, and MDA were significantly increased in the case group compared to the control group. The serum level of TAC was significantly lower in the case group than in the control group. Conclusion This study suggests that it is possible to diagnose patients with coronary artery disease (CAD) in the early stages of their disease and take preventive measures by measuring these parameters in serum. However, more research is needed before these serum parameters can be considered diagnostic biomarkers or therapeutic targets.en_US
dc.identifier.doi10.1002/jcla.23967
dc.identifier.issn0887-8013
dc.identifier.issn1098-2825
dc.identifier.issue10en_US
dc.identifier.pmid34492130en_US
dc.identifier.scopus2-s2.0-85114299783en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1002/jcla.23967
dc.identifier.urihttps://hdl.handle.net/11454/75922
dc.identifier.volume35en_US
dc.identifier.wosWOS:000695514900001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Clinical Laboratory Analysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectatherosclerosisen_US
dc.subjectcoronary artery disease (CAD)en_US
dc.subjectMannose-binding lectin (2)en_US
dc.subjecttenascin-Cen_US
dc.subjecttotal antioxidanten_US
dc.subjectCardiovascular-Diseaseen_US
dc.subjectHdl-Cholesterolen_US
dc.subjectRisk-Factorsen_US
dc.titleEvaluation of the serum levels of Mannose binding lectin-2, tenascin-C, and total antioxidant capacity in patients with coronary artery diseaseen_US
dc.typeArticleen_US

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