Effect of periodontal treatment on receptor activator of NF-?B ligand and osteoprotegerin levels and relative ratio in gingival crevicular fluid

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dc.contributor.authorBostanci N.
dc.contributor.authorSaygan B.
dc.contributor.authorEmingil G.
dc.contributor.authorAtilla G.
dc.contributor.authorBelibasakis G.N.
dc.date.accessioned2019-10-27T08:33:52Z
dc.date.available2019-10-27T08:33:52Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractAim: Receptor activator of NF-?B ligand (RANKL) and osteoprotegerin (OPG) have an established role in the pathogenesis of periodontitis, which is characterized by an increased RANKL/OPG ratio. The present study aims to investigate changes of RANKL, OPG and their relative ratio in gingival crevicular fluid (GCF) of periodontitis patients after non-surgical periodontal treatment. Materials and Methods: GCF was obtained from chronic periodontitis (n=14), generalized aggressive periodontitis (G-AgP; n=13) patients at baseline. The patients received scaling and root planing and were recalled after 2, 3 and 4 months for follow-up clinical examination and sampling. The total amounts and concentrations of RANKL and OPG in GCF were measured by enzyme-linked immunosorbent assay, and their relative ratio was calculated. Results: The RANKL/OPG ratio remained unchanged and did not correlate with clinical parameters throughout the monitoring period, despite the improved clinical outcome. This trend was similar in both chronic and G-AgP. Conclusions: Although the RANKL/OPG ratio has a potential diagnostic value for untreated periodontitis, it may not be a suitable predictor of clinically successful treatment outcome. As conventional therapy does not negatively modulate this ratio, the host could still be susceptible to further periodontal tissue destruction, warranting the consideration of adjunctive treatments. © 2011 John Wiley & Sons A/S.en_US
dc.identifier.doi10.1111/j.1600-051X.2011.01701.xen_US
dc.identifier.endpage433en_US
dc.identifier.issn0303-6979
dc.identifier.issue5en_US
dc.identifier.pmid21261673en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage428en_US
dc.identifier.urihttps://doi.org/10.1111/j.1600-051X.2011.01701.x
dc.identifier.urihttps://hdl.handle.net/11454/26907
dc.identifier.volume38en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Clinical Periodontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectELISAen_US
dc.subjectgingival crevicular fluiden_US
dc.subjectOPGen_US
dc.subjectperiodontal treatmenten_US
dc.subjectRANKLen_US
dc.subjectRANKL/OPG ratioen_US
dc.titleEffect of periodontal treatment on receptor activator of NF-?B ligand and osteoprotegerin levels and relative ratio in gingival crevicular fluiden_US
dc.typeArticleen_US

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