Effects of combined systemic administration of low-dose doxycycline and alendronate on endotoxin-induced periodontitis in rats

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dc.contributor.authorBuduneli E.
dc.contributor.authorVardar S.
dc.contributor.authorBuduneli N.
dc.contributor.authorBerdeli A.H.
dc.contributor.authorTürkoglu O.
dc.contributor.authorBaşkesen A.
dc.contributor.authorAtilla G.
dc.date.accessioned2019-10-27T00:13:07Z
dc.date.available2019-10-27T00:13:07Z
dc.date.issued2004
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Doxycycline has been widely used in periodontal treatment for its antimicrobial and anti-enzymatic effects. Recently, bisphosphonates have been shown to inhibit alveolar bone resorption. The aim of the present study was to evaluate the effects of doxycycline and the bisphosphonate alendronate on the gingival tissue levels of prostaglandin E2 (PGE2), prostaglandin F2? (PGF2?), leukotriene B4 (LTB4), and platelet-activating factor (PAF) in endotoxin-induced periodontal breakdown in rats. Methods: Experimental periodontitis was induced by repeated injection of Escherichia coli endotoxin (LPS) and 44 adult male Sprague-Dawley rats were divided into five study groups as follows: LPS, doxycycline + LPS, alendronate + LPS, doxycycline + alendronate + LPS, and saline control. Doxycycline and alendronate were given either as a single agent or as a combination therapy during the 7-day study period. At the end of the 1-week protocol, the rats were sacrificed, the gingival tissues were dissected and extracted, and the extracts were analyzed for PGE2, PGF2?, LTB4, and PAF levels. The defleshed jaws were analyzed morphometrically for alveolar bone loss. Data were evaluated statistically by using parametric tests. Results: Alveolar bone loss measurements revealed significantly higher values in LPS, doxycycline + LPS, alendronate + LPS, and doxycycline + alendronate + LPS groups in comparison to the saline control group (P <0.05). Combined administration of doxycycline and alendronate exhibited the most prominent inhibition on gingival tissue levels of PGE2 and PGF2?, (P<0.05). Doxycycline + alendronate + LPS group also significantly reduced LTB4 and PAF levels, although doxycycline provided the most reduction in the levels of these mediators (P <0.05). Conclusions: Alendronate and/or doxycycline may provide significant inhibition of the major inflammatory mediators of periodontal tissue destruction, and combined administration of these agents may provide beneficial effects in periodontal treatment. However, this hypothesis must be further verified by clinical human trials before introducing its use in dental practice.en_US
dc.identifier.doi10.1902/jop.2004.75.11.1516en_US
dc.identifier.endpage1523en_US
dc.identifier.issn0022-3492
dc.identifier.issue11en_US
dc.identifier.pmid15633329en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1516en_US
dc.identifier.urihttps://doi.org/10.1902/jop.2004.75.11.1516
dc.identifier.urihttps://hdl.handle.net/11454/22427
dc.identifier.volume75en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Periodontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlendronate/therapeutic useen_US
dc.subjectAlveolar bone lossen_US
dc.subjectAnimal studiesen_US
dc.subjectBisphosphonates/therapeutic useen_US
dc.subjectComparison studiesen_US
dc.subjectDoxycycline/therapeutic useen_US
dc.subjectPeriodontitis/drug therapyen_US
dc.subjectProstaglandinsen_US
dc.titleEffects of combined systemic administration of low-dose doxycycline and alendronate on endotoxin-induced periodontitis in ratsen_US
dc.typeArticleen_US

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