Transrektal prostat biyopsisi yapılan hastalarda prostat hacmi ile prostat kanseri arasındaki ilişki
Küçük Resim Yok
Tarih
2018
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Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Çalışmamızda, transrektal prostat biyopsisi yapılan hastalarda prostat hacmi ile prostat kanseri arasındaki bir ilişki olup olmadığının geriye dönük ve tek merkezli olarak araştırılması amaçlandı. Yöntem: Ocak 2014 ile Aralık 2016 arasında PSA yüksekliği veya şüpheli parmakla rektal inceleme bulgusu nedeni ilk defa prostat biyopsisi yapılan hastalar çalışmaya alındı. Çalışmada, hastaların yaşı, PSA değeri, parmakla rektal inceleme bulgusu, transrektal ultrasondaki prostat hacmi, alınan biyopsi kor sayısı, biyopsi patoloji sonucu ve Gleason skoru değerlendirildi. Bulgular: Çalışmaya 814 hasta dahil edildi. Hastaların ortalama PSA değeri 9,67±6,9 ng/ml idi ve hastaların 137’sinde (%15,6) anormal parmakla rektal inceleme bulgusu vardı. Çalışmadaki hastaların ortalama prostat hacmi 44,8±26,5 cm3 idi. Prostat hacmi 60 cm3 altı olan hasta sayısı 533 (%65,4) iken, prostat hacmi 60 cm3 üstü olan hasta sayısı 281 (%34,6) idi. Buna göre 60 cm3 altında prostat hacmi olan gruptaki hastalar istatistiksel anlamlı olarak daha gençti (61,1±9,4 vs. 67,2±8,7, p<0,05) ve daha düşük PSA değerine (7,9±5,3 vs. 13,5±9,1, p<0,05) sahip idi. Ayrıca 60 cm3 altı prostat hacmi olan hastaların 215’inde (%40,3) PK belirlenirken, 60 cm3 üstü prostat hacmi olan hastaların 64’ünde (%22,7) PK belirlenmişti (p<0,05). Prostat hacmi 60 cm3 altı ve 60 cm3 üstü olan hastalardaki Gleason skorları arasında istatistiksel anlamlı fark belirlenmemiştir (p=0,792). Sonuç: Çalışmamızda, PSA yüksekliği veya anormal parmakla rektal inceleme bulgusu nedeni ile transrektal prostat biyopsisi yapılan hastalarda, prostat hacmi 60 cm3 üzerinde ise daha az prostat kanseri belirlendiğini bulduk.
Objective: We retrospectively investigated whether any correlation existed between prostate volume and prostate cancer in patients who underwent transrectal prostate biopsy at a single tertiary center. Methods: Patients who underwent prostate biopsy for the first time due to increased serum PSA levels and suspicious findings on digital rectal examination between January 2014 and December 2016 were included in this study . Patient’s age, serum PSA level, findings on digital rectal examination, prostate volume, number of total number of prostate biopsy cores, pathological diagnosis of prostate biopsy (cancer/benign), and Gleason score were evaluated. Results: Eight-hundred fourteen patients were included the study. Mean PSA level was 9.67±6.9 ng/ml and 137 (15.6%) of 814 patients had abnormal digital rectal examination findings. Mean prostate volume was 44.8±26.5 cm3 . Patients divided into 2 groups: 533 (65.4%) of 814 patients had a prostate volume 60 cm3 and lower, 281 (34.6%) of 814 patients had a prostate volume greater than 60 cm3 . Patients with a prostate volume 60 cm3 and lower were statistically significantly younger (61.1±9.4 vs. 67.2±8.7, p<0.05) and had a lower serum PSA level (7.9±5.3 vs. 13.5±9.1, p<0.05). Diagnosis of prostate cancer was made in patients with a prostate volume 60 cm3 and lower (40.3% vs. 22.7%, p<0.05). Any statistically significant difference in Gleason scores of the patients with prostate volumes ? 60 cm3 , and > 60 cm3 (p=0.792). Conclusion: We found an association between prostate volume and prostate cancer diagnosis in patients who underwent transrectal prostate biopsy because of increased PSA levels or abnormality DRE findings Patients with a prostate volume higher than 60 cm3 had a decreased rate of prostate cancer diagnosis.
Objective: We retrospectively investigated whether any correlation existed between prostate volume and prostate cancer in patients who underwent transrectal prostate biopsy at a single tertiary center. Methods: Patients who underwent prostate biopsy for the first time due to increased serum PSA levels and suspicious findings on digital rectal examination between January 2014 and December 2016 were included in this study . Patient’s age, serum PSA level, findings on digital rectal examination, prostate volume, number of total number of prostate biopsy cores, pathological diagnosis of prostate biopsy (cancer/benign), and Gleason score were evaluated. Results: Eight-hundred fourteen patients were included the study. Mean PSA level was 9.67±6.9 ng/ml and 137 (15.6%) of 814 patients had abnormal digital rectal examination findings. Mean prostate volume was 44.8±26.5 cm3 . Patients divided into 2 groups: 533 (65.4%) of 814 patients had a prostate volume 60 cm3 and lower, 281 (34.6%) of 814 patients had a prostate volume greater than 60 cm3 . Patients with a prostate volume 60 cm3 and lower were statistically significantly younger (61.1±9.4 vs. 67.2±8.7, p<0.05) and had a lower serum PSA level (7.9±5.3 vs. 13.5±9.1, p<0.05). Diagnosis of prostate cancer was made in patients with a prostate volume 60 cm3 and lower (40.3% vs. 22.7%, p<0.05). Any statistically significant difference in Gleason scores of the patients with prostate volumes ? 60 cm3 , and > 60 cm3 (p=0.792). Conclusion: We found an association between prostate volume and prostate cancer diagnosis in patients who underwent transrectal prostate biopsy because of increased PSA levels or abnormality DRE findings Patients with a prostate volume higher than 60 cm3 had a decreased rate of prostate cancer diagnosis.
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp
Kaynak
İzmir Tepecik Eğitim Hastanesi Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
28
Sayı
1
