Design and synthesis of Tc-99m-citro-folate for use as a tumor-targeted radiopharmaceutical

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dc.contributor.authorAltiparmak, Burcu
dc.contributor.authorLambrecht, Fatma Yurt
dc.contributor.authorBayrak, Elif
dc.contributor.authorDurkan, Kubra
dc.date.accessioned2019-10-27T21:13:56Z
dc.date.available2019-10-27T21:13:56Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractFolate conjugates exhibit high affinity for folate receptor (FR) positive cells and tissues, such as those in tumors, making them attractive candidates and of interest in diagnostic tumor imaging. The aim of study was to synthesize a novel radiopharmaceutical based folate conjugate, Tc-99m-citro-folate, and to evaluate its efficiency as a targeted agent for imaging tumors that over express FR. TLC, HPLC H-1 NMR and LC-MS/MS methods were used to check and confirm the synthesized citro-folate. Citro-folate was labeled with Tc-99m with high labeling efficiency (97 +/- 1.0%). Biodistribution of the radiolabeled conjugate Tc-99m-citro-folate was investigated in vivo using two groups of rats: FR saturated and unsaturated. These experiments showed high uptake of Tc-99m-citro-folate in FR rich tissues and demonstrated its sensitivity and specificity in imaging ovary and uterus. Based on the demonstrated good radiolabeling and biodistribution properties, the compound Tc-99m-citro-folate may potentially be used as a radiopharmaceutical agent for imaging the FR-positive tumors. (C) 2010 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipDepartment of Scientific Projects at Ege University, Izmir, TurkeyEge Universityen_US
dc.description.sponsorshipThe authors gratefully acknowledge the financial support received from Department of Scientific Projects at Ege University, Izmir, Turkey.en_US
dc.identifier.doi10.1016/j.ijpharm.2010.08.002en_US
dc.identifier.endpage14en_US
dc.identifier.issn0378-5173
dc.identifier.issue01.Feben_US
dc.identifier.pmid20696224en_US
dc.identifier.startpage8en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijpharm.2010.08.002
dc.identifier.urihttps://hdl.handle.net/11454/43311
dc.identifier.volume400en_US
dc.identifier.wosWOS:000283829900002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofInternational Journal of Pharmaceuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTc-99m-citro-folateen_US
dc.subjectFolic aciden_US
dc.subjectCitric aciden_US
dc.subjectTumor imaging agenten_US
dc.subjectTc-99men_US
dc.titleDesign and synthesis of Tc-99m-citro-folate for use as a tumor-targeted radiopharmaceuticalen_US
dc.typeArticleen_US

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