Diverse effects of taurine on vascular response and inflammation in GSH depletion model in rabbits

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dc.contributor.authorOzsarlak-Sozer, G.
dc.contributor.authorSevin, G.
dc.contributor.authorOzgur, H. H.
dc.contributor.authorYetik-Anacak, G.
dc.contributor.authorKerry, Z.
dc.date.accessioned2019-10-27T23:10:27Z
dc.date.available2019-10-27T23:10:27Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractOBJECTIVE: A reduction in GSH and an increase in free radicals are observed in inflammatory diseases, indicating oxidative stress. Taurine protects cells from the cytotoxic effects of inflammation. There have been limited studies to date evaluating the effect of taurine in oxidative stress-induced vascular dysfunction and its role in vascular inflammatory diseases. Therefore, we aimed to investigate the effect of taurine on the regulation of vascular tonus and vascular inflammatory markers in rabbit aortae and carotid arteries in oxidative stress-induced by GSH depletion. MATERIALS AND METHODS: Rabbits were treated subcutaneously with buthionine sulfoximine (BSO), GSH-depleting compound and/or taurine. Cumulative concentration-response curves for acetylcholine (ACh), phenylephrine and 5-hydroxytriptamine (5-HT) were constructed with or without N-omega-nitro-L-arginine (LNA) in the carotid artery and aorta rings. Immunohistochemical staining was performed for TNF-alpha and IL-1 beta. RESULTS: BSO increased ACh-induced NOdependent relaxations, phenylephrine-induced contractions in the carotid artery and 5-HT induced-contractions in both the carotid artery and the aorta. BSO decreased EDHF dependent relaxations only in the aorta. ACh-induced NO-dependent relaxations and augmented contractions were normalized by taurine. BSO increased TNF-alpha expressions in both carotid arteries and aortas, which were reversed by taurine. The BSO-induced increase in IL-1 beta was reversed by taurine only in aortae. CONCLUSIONS: Treatment with BSO resulted in vascular reactivity changes and increased immunostaining of TNF-alpha in mainly carotid arteries in this model of oxidative stress. The effect of taurine on BSO-induced vascular reactivity changes varied depending on the vessel. The inhibition of the increase in TNF-alpha expression by taurine in both carotid arteries and aortae supports the proposal that taurine has a beneficial effect in the treatment of inflammatory diseases such as atherosclerosis.en_US
dc.description.sponsorshipEge University Scientific Research FundEge University [06ECZ008, 08ECZ019]en_US
dc.description.sponsorshipThis work was supported by grants from the Ege University Scientific Research Fund (06ECZ008, ZK) and (08ECZ019, ZK).en_US
dc.identifier.endpage1372en_US
dc.identifier.issn1128-3602
dc.identifier.issue7en_US
dc.identifier.pmid27097960en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1360en_US
dc.identifier.urihttps://hdl.handle.net/11454/52898
dc.identifier.volume20en_US
dc.identifier.wosWOS:000376904300025en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectButhionine sulfoximineen_US
dc.subjectAtherosclerosisen_US
dc.subjectTaurineen_US
dc.subjectInflammationen_US
dc.subjectRabbiten_US
dc.titleDiverse effects of taurine on vascular response and inflammation in GSH depletion model in rabbitsen_US
dc.typeArticleen_US

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