Cytomegalovirus Experience in Pediatric Kidney Transplantation in 26 Years’ Time

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dc.contributor.authorKeskinoglu, A.
dc.contributor.authorBulut, İ.K.
dc.contributor.authorTaner, S.
dc.contributor.authorTurkes, A.Z.
dc.contributor.authorKabasakal, C.
dc.date.accessioned2020-12-01T11:52:19Z
dc.date.available2020-12-01T11:52:19Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction: In this study,we investigated the presence of cytomegalovirus (CMV) infection in kidney transplanted children and its effect on kidney dysfunction. Material and Methods: One hundred thirty-five pediatric renal transplant patients were included in this study. The presence of CMV infection, CMV risk status, and other clinical features of the patients were evaluated retrospectively. Results: Fifty-three percent of all patients and 68.8% of patients with CMV were male. The mean age was 12 years in all patients and CMV groups. According to the CMV risk classification, 40.9% of the patients with CMV infection/disease were in the high-risk group (CMV D+R-). In CMV risk groups, the presence of CMV infection/disease was similar. Cold ischemia time, male sex (patients and donors), deceased donor, higher HLA-mismatches, and cumulative antithymocyte globulin dose were found as risk factors for CMV infection/disease. Acute rejection/graft failure was observed in 27% of all patients. CMV infection has no effect on rejection/graft failure and survival. Discussion: The frequency and risk factors of CMV in renal transplant children in our study were consistent with the literature. Conclusions: CMV infection was found in one-fifth of our patients and the majority (71.9%) of them developed infection in the first 6 months. In one-third of our patients acute rejection/graft failure was observed. There was no effect of CMV infection on rejection/graft failure and survival in pediatric patients with proper and effective treatment. © 2020en_US
dc.description.sponsorshipWe would like to thank Prof Dr Pembe Keskino?lu for data analysis and their collaborations in this study.en_US
dc.identifier.doi10.1016/j.transproceed.2020.03.023en_US
dc.identifier.endpage3191en_US
dc.identifier.issn0041-1345
dc.identifier.issue10en_US
dc.identifier.pmid32646585en_US
dc.identifier.scopus2-s2.0-85087527485en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage3186en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2020.03.023
dc.identifier.urihttps://hdl.handle.net/11454/61502
dc.identifier.volume52en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Inc.en_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleCytomegalovirus Experience in Pediatric Kidney Transplantation in 26 Years’ Timeen_US
dc.typeArticleen_US

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