The clinical and cognitive spectrum of locked-in syndrome: 1-year follow-up of 100 patients

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dc.authoridKumral, Emre/0000-0002-3105-7734
dc.authoriddorukoglu, mehmet mesut/0000-0002-2901-9843
dc.authorscopusid7003717249
dc.authorscopusid57223606429
dc.authorscopusid57223620138
dc.authorscopusid57223616502
dc.contributor.authorKumral, Emre
dc.contributor.authorDorukoglu, Mesut
dc.contributor.authorUzunoglu, Cansu
dc.contributor.authorCetin, Fatma Ece
dc.date.accessioned2023-01-12T19:51:45Z
dc.date.available2023-01-12T19:51:45Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractIn patients with locked-in syndrome (LIS), it is not known exactly to what extent cognitive functions are preserved and it is not known exactly how much it has improved. We aimed to examine the clinical and cognitive features of LIS 1 year after stroke. One hundred patients with locked-in syndrome (LIS) were recruited between January 2008 and May 2019 among 8200 patients with ischemic stroke. Patients were classified into two groups as single pontine infarcts (n = 72), and pontine plus multiple ischemic lesions (PMIL) (n = 28). Since the patients had limited motor and verbal response, the cognitive status of the patients in the early and late stages was evaluated with the Short Neuropsychological Questionnaire for Disabled Patients (SNQDP) test. At the onset of stroke, orientation to time and place was normal in 43% of patients with a single infarct compared with 18% of those with PMIL (OR 3.48; 95% CI 1.10-10.18; P = 0.015). There was no sustained visual fixation or tracking in 53% of patients with a single pontine infarct and 82% of those with PMIL (OR 4.12; 95% CI 1.41-12.02; P = 0.005). After 1-year follow-up, there was significant difference between patients with a single infarct and those with PMIL regarding to perception and execution, especially complex command follow (P = 0.042), attention span and concentration (P = 0.30), intelligible verbalization (P = 0.022). There was relatively high incidence (24%) of patients with a good outcome (mRS = 3) in those with single infarct. Given as in our study that many patients can show significant improvement in LIS, we recommend aggressive supportive measures, intense physical, speech and cognitive therapy to facilitate interaction with others and the environment.en_US
dc.identifier.doi10.1007/s13760-021-01675-5
dc.identifier.endpage121en_US
dc.identifier.issn0300-9009
dc.identifier.issn2240-2993
dc.identifier.issue1en_US
dc.identifier.pmid33987814en_US
dc.identifier.scopus2-s2.0-85105909183en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage113en_US
dc.identifier.urihttps://doi.org/10.1007/s13760-021-01675-5
dc.identifier.urihttps://hdl.handle.net/11454/76323
dc.identifier.volume122en_US
dc.identifier.wosWOS:000650108000002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofActa Neurologica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLocked-in syndromeen_US
dc.subjectConsciousnessen_US
dc.subjectBrainstemen_US
dc.subjectCognitive disorderen_US
dc.subjectStrokeen_US
dc.subjectLifeen_US
dc.titleThe clinical and cognitive spectrum of locked-in syndrome: 1-year follow-up of 100 patientsen_US
dc.typeArticleen_US

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