Effects of resveratrol on ovarian morphology, plasma anti-mullerian hormone, IGF-1 levels, and oxidative stress parameters in a rat model of polycystic ovary syndrome

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dc.contributor.authorErgenoglu M.
dc.contributor.authorYildirim N.
dc.contributor.authorYildirim A.G.S.
dc.contributor.authorYeniel O.
dc.contributor.authorErbas O.
dc.contributor.authorYavasoglu A.
dc.contributor.authorTaskiran D.
dc.contributor.authorKaradadas N.
dc.date.accessioned2019-10-26T21:21:59Z
dc.date.available2019-10-26T21:21:59Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: To evaluate the effects of resveratrol in a rat model of polycystic ovarian syndrome (PCOS). Study Design: After PCOS model was formed by subcutaneous dihydrotestosterone pellets, rats were randomly divided into 2 groups. The first group (n = 7) was treated with 1 mL/kg/d isotonic saline and the second group (n = 7) was treated with 10 mg/kg/d resveratrol. Seven rats were taken as controls without any medication. Results: Our results showed (1) significant reduction in the number of antral follicle counts (P < .01); (2) significantly decreased plasma anti-Mullerian hormone and insulin-like growth factor 1 levels (P < .01 and P < .05, respectively); (3) significantly lower superoxide dismutase activity (P < .05); and (4) significantly increased glutathione peroxidase content (P < .01) following resveratrol treatment. Conclusion: Resveratrol appears to be effective in the treatment of PCOS due to its antioxidant properties. Future clinical studies with different dosages might provide useful implementations to our practice. © The Author(s) 2015.en_US
dc.identifier.doi10.1177/1933719115570900en_US
dc.identifier.endpage947en_US
dc.identifier.issn1933-7191
dc.identifier.issue8en_US
dc.identifier.pmid25667201en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage942en_US
dc.identifier.urihttps://doi.org/10.1177/1933719115570900
dc.identifier.urihttps://hdl.handle.net/11454/16927
dc.identifier.volume22en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSAGE Publications Inc.en_US
dc.relation.ispartofReproductive Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectanti-Mullerian hormoneen_US
dc.subjectoxidative stressen_US
dc.subjectpolycystic ovary syndromeen_US
dc.subjectrat modelen_US
dc.subjectresveratrolen_US
dc.titleEffects of resveratrol on ovarian morphology, plasma anti-mullerian hormone, IGF-1 levels, and oxidative stress parameters in a rat model of polycystic ovary syndromeen_US
dc.typeArticleen_US

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