Advances in microfluidic synthesis and coupling with synchrotron SAXS for continuous production and real-time structural characterization of nano-self-assemblies

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dc.authoridYaghmur, Anan/0000-0003-1608-773X
dc.authoridAyisigi, Esra Ilhan/0000-0003-1880-4261
dc.authoridBor, Gizem/0000-0002-3322-900X
dc.authorid, Burcu/0000-0002-7869-647X
dc.authoridYesil-Celiktas, Ozlem/0000-0003-4509-2212
dc.authorwosidYaghmur, Anan/AGU-9381-2022
dc.authorwosidAyisigi, Esra Ilhan/AAA-8180-2021
dc.authorwosidYesil-Celiktas, Ozlem/AAI-5713-2020
dc.authorwosidBor, Gizem/AAT-7939-2021
dc.contributor.authorIlhan-Ayisigi, Esra
dc.contributor.authorYaldiz, Burcu
dc.contributor.authorBor, Gizem
dc.contributor.authorYaghmur, Anan
dc.contributor.authorYesil-Celiktas, Ozlem
dc.date.accessioned2023-01-12T19:54:37Z
dc.date.available2023-01-12T19:54:37Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractMicrofluidic platforms have become highly attractive tools for synthesis of nanoparticles, including lipid nano-self-assemblies, owing to unique features and at least three important aspects inherent to miniaturized micro-devices. Firstly, the fluids flow under controlled conditions in the microchannels, providing well-defined flow profiles and shorter diffusion lengths that play important roles in enhancing the continuous production of lipid and polymer nanoparticles with relatively narrow size distributions. Secondly, various geometries adapted to microfluidic device designs can be utilized for enhancing the colloidal stability of nanoparticles and improving their drug loading. Thirdly, microfluidic devices are usually compatible with in situ characterization methods for real-time monitoring of processes occurring inside the microchannels. This is unlike conventional nanoparticle synthesis methods, where a final solution or withdrawn aliquots are separately analysed. These features inherent to microfluidic devices provide a tool-set allowing not only precise nanoparticle size control, but also real-time analyses for process optimization. In this review, we focus on recent advances and developments in the use of microfluidic devices for synthesis of lipid nanoparticles. We present different designs based on hydrodynamic flow focusing, droplet-based methods and controlled microvortices, and discuss integration of microfluidic platforms with synchrotron small-angle X ray scattering (SAXS) for in situ structural characterization of lipid nano-self-assemblies under continuous flow conditions, along with major challenges and future directions in this research area.en_US
dc.description.sponsorshipINP grant from the Danish Agency for Science and Higher Education [8073-00022B]en_US
dc.description.sponsorshipAY and OYC acknowledge the INP grant (Ref. no.: 8073-00022B) from the Danish Agency for Science and Higher Education for initiating and exploring new networking and collaboration opportunities between Danish and Turkish research institutions.en_US
dc.identifier.doi10.1016/j.colsurfb.2021.111633
dc.identifier.issn0927-7765
dc.identifier.issn1873-4367
dc.identifier.pmid33639513en_US
dc.identifier.urihttps://doi.org/10.1016/j.colsurfb.2021.111633
dc.identifier.urihttps://hdl.handle.net/11454/76481
dc.identifier.volume201en_US
dc.identifier.wosWOS:000674636500003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofColloids and Surfaces B-Biointerfacesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNano-self- assembliesen_US
dc.subjectMicrofluidicsen_US
dc.subjectIn situ characterizationen_US
dc.subjectSAXSen_US
dc.subjectSample-Preparation Platformen_US
dc.subjectDrug-Delivery Systemsen_US
dc.subjectLipid Nanoparticlesen_US
dc.subjectNanoscale Liposomesen_US
dc.subjectPhase-Transitionsen_US
dc.subjectFlow Cytometeren_US
dc.subjectGene Deliveryen_US
dc.subjectSizeen_US
dc.subjectNanostructureen_US
dc.subjectPhospholipidsen_US
dc.titleAdvances in microfluidic synthesis and coupling with synchrotron SAXS for continuous production and real-time structural characterization of nano-self-assembliesen_US
dc.typeArticleen_US

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