Heterogeneity of subclinical autistic traits among parents of children with autism spectrum disorder: Identifying the broader autism phenotype with a data-driven method

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dc.contributor.authorBora, Emre
dc.contributor.authorAydin, Aydan
dc.contributor.authorSarac, Tugba
dc.contributor.authorKadak, Muhammed Tayyib
dc.contributor.authorKose, Sezen
dc.date.accessioned2019-10-27T11:10:39Z
dc.date.available2019-10-27T11:10:39Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractClinical diagnosis of autism spectrum disorder (ASD) can be conceptualized as the extreme end of the distribution of subclinical autistic traits related to genetic susceptibility factors (broad autism phenotype (BAP)) in the general population. Subclinical autistic traits are significantly more common among unaffected first-degree relatives of probands with autism. However, there is a significant heterogeneity of autistic traits in family members of individuals with ASD and severity of autistic traits are not significantly different from controls in the majority of these relatives. The current study investigated the heterogeneity of autistic traits using latent class analysis (LCA) of the Autism Spectrum Quotient (AQ) ratings of 673 parents of children with ASD and 147 parents of typically developing children. Two distinct subgroups, including a "low-scoring" and a "high-scorer (BAP)" groups, were found. In comparison to control parents, a significantly larger proportion (21.1% vs. 7.5%) of parents of ASD were members of BAP group. Communication subscale made a distinctive contribution to the separation of high and low-scoring groups (d=2.77). Further studies investigating neurobiological and genetic biomarkers and stability of these two subgroups over time are important for understanding the nature of autistic traits in the general population. Autism Res2017, 10: 321-326. (c) 2016 International Society for Autism Research, Wiley Periodicals, Inc.en_US
dc.identifier.doi10.1002/aur.1661en_US
dc.identifier.endpage326en_US
dc.identifier.issn1939-3792
dc.identifier.issn1939-3806
dc.identifier.issue2en_US
dc.identifier.pmid27383033en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage321en_US
dc.identifier.urihttps://doi.org/10.1002/aur.1661
dc.identifier.urihttps://hdl.handle.net/11454/32416
dc.identifier.volume10en_US
dc.identifier.wosWOS:000395645700012en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAutism Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectautistic traitsen_US
dc.subjectautism-spectrum questionnaireen_US
dc.subjectlatent class analysisen_US
dc.subjectbroader autism phenotypeen_US
dc.titleHeterogeneity of subclinical autistic traits among parents of children with autism spectrum disorder: Identifying the broader autism phenotype with a data-driven methoden_US
dc.typeArticleen_US

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